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Human Experimentation

Methodologic issues fundamental to clinical trials

  • Book
  • © 1999

Overview

Authors:
  1. Ton J. Cleophas

    1. European Diploma of Pharmaceutical Medicine, Albert Schweitzer Hospital Dordrecht, Netherlands

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Placebos

    • Ton J. Cleophas
    Pages 1-6

  3. Fundamental Issues of Choosing the Right Type of Trial

    • Ton J. Cleophas
    Pages 7-14

  4. Lack of Real Science of Symtom-Based Care

    • Ton J. Cleophas
    Pages 15-24

  5. Carryover Effects in Clinical Research

    • Ton J. Cleophas
    Pages 25-36

  6. Clinical Trials: Relevance of Correlation Between Treatment Responses

    • Ton J. Cleophas
    Pages 37-47

  7. Between-Group Disparities in Drug Response

    • Ton J. Cleophas
    Pages 48-56

  8. Specific Problems with Trials of Chronic Diseases

    • Ton J. Cleophas
    Pages 57-65

  9. Clinical Trials: New Endpoints

    • Ton J. Cleophas
    Pages 66-72

  10. Linear Scale Assessment of Relevant Domains of Quality of Life an example

    • Ton J. Cleophas
    Pages 73-80

  11. Item Response Modeling and Quality of Life

    • Ton J. Cleophas
    Pages 81-89

  12. Is Selective Reporting of Well-Designed Clinical Research Unethical as Well as Unscientific?

    • Ton J. Cleophas
    Pages 90-98

  13. Informed Consent Under Scrutiny, Suggestions for Improvement

    • Ton J. Cleophas
    Pages 99-106
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Keywords

About this book

Despite their effectiveness in the evaluation of new pharmacological compounds, controlled clinical trials are sometimes inadequate. Using data from the literature as well as from the author's own experience with clinical trials, Human Experimentation: Methodologic Issues Fundamental to Clinical Trials addresses such inadequacies and tries to provide solutions. This work is the first to thoroughly examine these unsolved inadequacies and problems with the design and the execution of clinical trials and, more importantly, to provide solutions for these problems. It is important for anyone who is involved in clinical research: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and anyone who is involved in applying results of research to patients, i.e. physicians.

Authors and Affiliations

  • European Diploma of Pharmaceutical Medicine, Albert Schweitzer Hospital Dordrecht, Netherlands

    Ton J. Cleophas

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