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Drugs Looking for Diseases

Innovative Drug Research and the Development of the Beta Blockers and the Calcium Antagonists

  • Book
  • © 1991

Overview

Authors:
  1. Rein Vos

    1. Department of Pharmacology and Pharmacotherapeutics, University Centre for Pharmacy, University of Groningen, Groningen, The Netherlands

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 120)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xxix
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  2. The controlled clinical trial — A model for the intricate relationships between clinical medicine and drug research

    • Rein Vos
    Pages 1-19

  3. The architecture of drug discovery

    • Rein Vos
    Pages 21-70

  4. Experimental and therapeutic profiling in drug innovation: the early history of the beta blockers

    • Rein Vos
    Pages 71-79

  5. Industrial research and beta blockade

    • Rein Vos
    Pages 81-122

  6. Verapamil: dying drug or sleeping beauty?

    • Rein Vos
    Pages 123-155

  7. Metamorphosis of a disease Profiles of angina pectoris in Anglo-American medicine

    • Rein Vos
    Pages 157-184

  8. Targeting in drug research and the medical scene

    • Rein Vos
    Pages 185-237

  9. Search processes, profiles and therapeutic practice in drug discovery

    • Rein Vos
    Pages 239-266

  10. The enigma of drug discovery

    • Rein Vos
    Pages 267-279

  11. Back Matter

    Pages 281-381
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Keywords

About this book

We all know how much time, effort and money it takes to develop a new drug. Hundreds of chemical compounds have to be synthesized and thousands of different activities in biology, physiology, pharmacology, clinical investigation, management and marketing have to be initiated and coordinated. Each new drug starts a voyage of discovery through an unmapped terrain which is shrouded in mist and beset by pitfalls, as Dr. Rein Vos puts it in his absorbing inside story of the development of the beta-adrenoceptor blocking agents and the calcium antagonists. Indeed we know, for example, how long it took before the theory of Ahlquist of the alpha and beta adrenergic receptors was widely accepted. Similarly, it suffices to memorize shortly the difficulty of expanding the new concept of calcium antagonism through the national German boundaries into the world. This shows how laborious and complex pharmaceutical progress is, and we all will benefit from a deeper understanding of the process of innovative drug research.

Authors and Affiliations

  • Department of Pharmacology and Pharmacotherapeutics, University Centre for Pharmacy, University of Groningen, Groningen, The Netherlands

    Rein Vos

Bibliographic Information

  • Book Title: Drugs Looking for Diseases

  • Book Subtitle: Innovative Drug Research and the Development of the Beta Blockers and the Calcium Antagonists

  • Authors: Rein Vos

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-011-3796-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1991

  • Hardcover ISBN: 978-0-7923-0968-0Published: 31 December 1990

  • Softcover ISBN: 978-94-010-5689-2Published: 31 October 2012

  • eBook ISBN: 978-94-011-3796-6Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XXX, 381

  • Topics: Cardiology, Philosophy of Medicine

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