Molecular Basis of Specificity in Nucleic Acid-Drug Interactions

1. Front Matter

   Pages i-x

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2. Mutual Conformational Adaptation of Both Ligand and Receptor in Antitumor Drug-DNA Complexes

   • Andrew H.-J. Wang, Yen-Chywan Liaw, Howard Robinson, Yi-Gui Gao

   Pages 1-21

3. DNA Drug Interactions Studied with Polarized Light Spectroscopy: The DAPI Case

   • B. Nordén, S. Eriksson, S. K. Kim, M. Kubista, R. Lyng, B. Åkerman

   Pages 23-41

4. Drug-DNA Recognition: Sequence-Specificity of the DNA Minor Groove Binder Berenil

   • S. Neidle, D. G. Brown, T. C. Jenkins, C. A. Laughton, M. R. Sanderson, J. V. Skelly

   Pages 43-57

5. Binding of Minor Groove Ligands to Short DNA Segments: Berenil Complexed with d(GCAATTGC)2 and d(GCTTAAGC)2

   • Richard H. Shafer, Mitsuru Yoshida, Debra L. Banville, Sungho Hu

   Pages 59-65

6. The sequence specificity of damage caused by [125I]-labelled Hoechst 33258 and UV / iodoHoechst 33258 in intact cells and in cloned sequences of purified DNA which differ by a small number of base substitutions

   • Vincent Murray

   Pages 67-73

7. Structure and Dynamics of a [1:1] Drug-DNA Complex: Analysis of 2D NMR Data Using Molecular Mechanics and Molecular Dynamics Calculations

   • Ramaswamy H. Sarma, Mukti H. Sarma, Kimiko Umemoto, Goutam Gupta, Angel E. Garcia

   Pages 75-93

8. Determination of Distamycin-A Binding Modes by NMR

   • D. E. Wemmer, P. Fagan, J. G. Pelton

   Pages 95-101

9. Molecular Mechanisms of DNA Sequence Recognition by Groove Binding Ligands: Biochemical and Biological Consequences

   • J. William Lown

   Pages 103-122

10. Daunomycin Binding to DNA: From the Macroscopic to the Microscopic

    • Jonathan B. Chaires

    Pages 123-136

11. In Vitro Transcription Analysis of the Sequence Specificity of Reversible and Irreversible Complexes of Adriamycin with DNA

    • D. R. Phillips, C. Cullinane, H. Trist, R. J. White

    Pages 137-155

12. Quantitative Footprinting Analysis of the Actinomycin D-DNA Interaction

    • Robert Rehfuss, Jerry Goodisman, James C. Dabrowiak

    Pages 157-166

13. Structural Requirements for DNA Topoisomerase II Inhibition by Anthracyclines

    • G. Capranico, F. Zunino

    Pages 167-176

14. Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids

    • D. E. Graves, R. M. Wadkins

    Pages 177-189

15. Kinetic and Equilibrium Binding Studies of a Series of Intercalating Agents That Bind by Threading a Sidechain through the DNA Helix

    • Laurence P. G. Wakelin, William A. Denny

    Pages 191-206

16. Aminoacyl-Anthraquinones: DNA-Binding and Sequence Specificity

    • Manlio Palumbo, Barbara Gatto

    Pages 207-224

17. The Molecular Basis of Specific Recognition between Echinomycin and DNA

    • M. J. Waring

    Pages 225-245

18. Bis-Pyrrolecarboxamides Linked to Intercalating Chromophore Oxazolopyridocarbazole (OPC): Properties Related to the Selective Binding to DNA at Rich Sequences

    • C. Auclair, F. Subra, D. Mrani, G. Gosselin, J. L. Imbach, C. Paoletti

    Pages 247-260

19. Parallel-Stranded Nucleic Acids and Their Interaction with Intercalating and Groove Binding Drugs

    • Johan H. van de Sande, Bernd W. Kalisch, Markus W. Germann

    Pages 261-274

20. Design of Bifunctional Nucleic Acid Ligands

    • T. Montenay-Garestier, J. S. Sun, J. Chomilier, J. L. Mergny, M. Takasugi, U. Asseline et al.

    Pages 275-290

One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.

• biochemistry
• chemistry
• nucleic acid

• Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

  Bernard Pullman

• Department of Chemistry, University of Tel-Aviv, Israel

  Joshua Jortner

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