Coronary Blood Flow

1. Front Matter

   Pages i-xxiii

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2. Basic coronary physiology

   • Jos A. E. Spaan

   Pages 1-36

3. Structure and function of the coronary arterial tree

   • Jos A. E. Spaan

   Pages 37-67

4. Structure and perfusion of the capillary bed

   • Jos A. E. Spaan

   Pages 69-86

5. Structure and function of coronary venous system

   • Jos A. E. Spaan

   Pages 87-98

6. Linear system analysis applied to the coronary circulation

   • Jos A. E. Spaan

   Pages 99-129

7. Interaction between contraction and coronary flow: Theory

   • Jos A. E. Spaan

   Pages 131-162

8. Interaction between contraction and coronary flow: Experiment

   • Jos A. E. Spaan

   Pages 163-191

9. Arteriolar mechanics and control of flow

   • Ed van Bavel, Maurice J. M. M. Giezeman, Jos A. E. Spaan

   Pages 193-218

10. Static and dynamic analysis of local control of coronary flow

    • Jenny Dankelman, Isabelle Vergroesen, Jos A. E. Spaan

    Pages 219-259

11. Water balance within the myocardium

    • Isabelle Vergroesen, Yves Han, Jenny Dankelman, Jos A. E. Spaan

    Pages 261-289

12. Oxygen exchange between blood and tissue in the myocardium

    • Jos A. E. Spaan, Peter A. Wieringa

    Pages 291-332

13. Limitation of coronary flow reserve by a stenosis

    • Jos A. E. Spaan, Jan Verburg

    Pages 333-361

14. Back Matter

    Pages 363-396

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by JULIEN IE HOFFMAN One of the earliest coronary physiologists was Scaramucci who, in 1695, postu­ lated that during systole the contracting myocardium inhibited coronary blood flow. Since then, the many contributions that have been made to our knowledge of the coronary circulation can be arbitrarily divided into three phases based on advances in technical methods. The early phase of research into the coronary circulation, done with great difficulty with crude methods, may be regarded as ending in the 1940s, and it included major discoveries made by such well known investigators as Georg von Anrep, Ernest Starling, Carl Wiggers, and Louis Katz, who formulated much of our basic understanding of the field. After 1940, the field of coronary physiology entered a new phase when instruments for high fidelity registration of coronary flow and pressure became available. This era was domi­ nated by Donald Gregg who combined careful attention to the function of these instruments (some of which he helped to develop) with an extraordinary ability to discern mechanisms from apparently minor changes in coronary flow and pressure patterns. His book 'The Coronary Circulation in Health and Disease' set a new standard in the field. After 1960, techniques for measuring regional myocardial blood flow became available, and enabled a large group of eminent investigators to make major advances in understanding the physiology and pathophysiology of myocardial blood flow.

• arterial pressure
• cells
• heart rate
• physiology
• tissue

'In Summary, this is an excellent compendium of the current state of our knowledge on coronary haemodynamics and I recommend it to anyone who works with the perfused heart.' Cardiovascular Research 1992

• Cardiovascular Research Institute Amsterdam (CRIA), Amsterdam, The Netherlands

  Jos A. E. Spaan

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