Overview
- Authors:
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Peter H. Bach
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The Nephrotoxicity Research Group, School of Science, Polytechnic of East London, London, UK
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John Baker
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CIBA-GEIGY Pharmaceuticals, West Sussex, UK
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Table of contents (11 chapters)
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- Benjamin F. Trump, Irene K. Berezesky, Alan C. Morris
Pages 71-101
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- M. G. Ormerod, J. A. Green
Pages 103-118
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- Cornelis J. F. Van Noorden, Reinhart Gossrau
Pages 119-145
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- Peter Bannasch, Hans Jörg Hacker, Fritz Klimek, Doris Mayer, Heide Zerban
Pages 187-223
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- Neill J. Gregg, Martin F. Wilks, Peter H. Bach
Pages 225-253
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Back Matter
Pages 275-289
About this book
Toxicological and pharmacological effects arise when chemicals interact with biophysiological functions in discrete cell types. There is a continuing need to screen novel compounds for their potential therapeutic effects, and once these have been "discovered" to understand their molecular actions, as the basis of using such compounds safely and for rational drug design. Pharmacology now uses all of the sophisticated molecular research techniques that are available for the development of safer and more efficacious drugs. Histochemistry has been usefully applied to developing new drugs (and assessing chemical safley) and is potentially cost effective. The need to test novel substances for their potential adverse effects has raised many questions. Toxicological pathology has moved away from the cataloging of lesions towards understanding the basis of the events that underly cell injury, especially for those secondary consequences of chemical injury that lead to malignancy and chronic disease. The focal nature of toxicologic lesions de mands the use of microtechniques to provide data to help understand these questions. Histochemistry is under-utilized, but offers one of the key ap proaches necessary to address the problem of understanding interactions between a cell population and a chemical, the modulation of cellular biochem istryor the presence of a lesion in a test animal can be rationalised in terms of species differences that have no relevance to man as opposed to those that are of clinical significance or represent a warning of dire consequences to man.
Reviews
Histochemical and immunohistochemical techniques is a vital source of practical information for academic and industrial workers. . - Biomedicine and Pharmacology
Authors and Affiliations
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The Nephrotoxicity Research Group, School of Science, Polytechnic of East London, London, UK
Peter H. Bach
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CIBA-GEIGY Pharmaceuticals, West Sussex, UK
John Baker
