Biochemistry of Inflammation

1. Front Matter

   Pages i-xii

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2. An overview of the inflammatory response

   • S. W. Evans, J. T. Whicher

   Pages 1-15

3. The complement system and inflammation

   • A. R. McPhaden, K. Whaley

   Pages 17-36

4. The kinin system: current concepts and perspectives

   • D. Regoli, N.-E. Rhaleb, G. Drapeau, S. Dion

   Pages 37-55

5. Role of cellular proteinases and their protein inhibitors in inflammation

   • J. F. Woessner Jr.

   Pages 57-89

6. Eicosanoids (prostaglandins and leukotrienes)

   • E. R. Pettipher, G. A. Higgs, J. A. Salmon

   Pages 91-108

7. The role of toxic oxygen species in inflammation with special reference to DNA damage

   • P. G. Winyard, D. Perrett, G. Harris, D. R. Blake

   Pages 109-129

8. Glucocorticoids and lipocortin

   • S. H. Peers, R. J. Flower

   Pages 131-146

9. Platelet activating factor and cytokine feedback regulation of endothelial integrity; implications for the treatment of inflammatory disease

   • D. Hosford, M. Paubert-Braquet, P. Braquet

   Pages 147-175

10. A role for neuropeptides in inflammation

    • C. W. Denko

    Pages 177-181

11. Interleukin 1 as an inflammatory mediator

    • J. A. Symons, J. A. Eastgate, G. W. Duff

    Pages 183-210

12. Tumour necrosis factor (TNF) and inflammation

    • P. J. McLaughlin

    Pages 211-223

13. Interleukin 6: a consequence of inflammation

    • S. W. Evans

    Pages 225-241

14. The acute phase response

    • J. T. Whicher, C. I. Westacott

    Pages 243-269

15. The role of leukocyte chemotaxis in inflammation

    • A. Rot

    Pages 271-304

16. Back Matter

    Pages 305-313

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Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated.
The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself.
This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.

• biochemistry
• cytokine
• inflammation
• molecular biology
• necrosis
• tumor

• Department of Chemical Pathology and Immunology, Old Medical School, Leeds, UK

  J. T. Whicher, S. W. Evans

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