Side-Effects of Anti-Inflammatory Drugs 3

1. Front Matter

   Pages i-xx

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2. Epidemiology

   1. The gastrointestinal toxicity of the non-steroidal anti-inflammatory drugs

      • Jeffrey L. Carson, Brian L. Strom

      Pages 1-8

   2. The value of the case—control approach for the evaluation of the risk of upper gastrointestinal bleeding associated with the previous use of non-steroidal anti-inflammatory drugs

      • J. R. Laporte, X. Carné, A. Figueras, X. Vidal, J. Juan

      Pages 9-17

   3. Liver toxicity of antipyretic drugs in conjunction with measles infections

      • Micha Levy, Zvi Ackerman

      Pages 18-21

   4. Non-steroidal anti-inflammatory drugs and hypersensitivity reactions

      • Brian L. Strom, Jeffrey L. Carson, Rita Schinnar, Ellen Sim Snyder, Suzanne West

      Pages 22-26

   5. What can a spontaneous reporting system teach about side-effects of anti-inflammatory drugs?

      • George E. Ehrlich

      Pages 27-32

   6. Adverse reactions to NSAIDs: Consecutive evaluation of 30,000 patients in rheumatology

      • K. Brune, H. Fenner, M. Kurowski, R. Lanz

      Pages 33-42

3. Gastrointestinal Tract: Clinical Aspects

   1. The evaluation of acute gastrointestinal toxicity of NSAIDs in phase I clinical trials: a critical appraisal

      • A. Del Favero, L. Patoia, L. Santucci

      Pages 43-53

   2. The ulcerogenic and anti-haemostatic effects of NSAIDs in the gut

      • C. J. Hawkey

      Pages 54-58

   3. What role does Helicobacter pylori infection play in NSAID-associated gastric inflammation?

      • J. S. A. Collins

      Pages 59-63

   4. Endoscopic evaluation of NSAID ulceration

      • Frank L. Lanza

      Pages 64-68

   5. Food antigen absorption in rheumatoid arthritis: effect of acetylsalicylic acid

      • U. Fiocco, U. Fagiolo, R. Paganelli, L. Cozzi, M. Rosada, E. Cozzi et al.

      Pages 69-79

   6. Intestinal mucosal permeability in inflammatory rheumatic diseases

      • H. Mielants, E. M. Veys, S. Goemaere, M. De Vos, C. Cuvelier, M. Maertens et al.

      Pages 80-88

   7. Comparison of effects on gastrointestinal blood loss and gastric mucosal appearance of piroxicam-β-cyclodextrin, piroxicam and placebo

      • S. Warrington, N. Debbas, M. Farthing, M. Horton, A. Thillainayagam, A. Umile

      Pages 89-96

4. Gastrointesinal Tract: Prevention of Adverse Effects

   1. Mechanisms of gastrointestinal ulceration from non-steroidal anti-inflammatory drugs: a basis for use and development of protective agents

      • K. D. Rainsford

      Pages 97-114

   2. Novel strategies of gastric and duodenal mucosal protection against NSAID injury: role of protease inhibitors, muscle relaxants and growth factors

      • S. Szabo, E. Gyomber, R. E. Morales, L. Nagy, P. Vattay

      Pages 115-125

   3. The role of misoprostol in preventing NSAID-induced damage to the gastrointestinal tract

      • Paul A. Nicholson

      Pages 126-134

   4. Possible factors involved in the protective effects of interleukin-1 in aspirin- and indomethacin-induced gastric damage

      • Kenneth G. Mugridge, Mauro Perretti, John L. Wallace, Luca Parente

      Pages 135-144

   5. Prevention and treatment of NSAID-gastroduodenal damage: the role of H2-receptor antagonists

      • G. Bianchi Porro, S. Ardizzone

      Pages 145-153

   6. Omeprazole in the prevention and therapy of gastroduodenal lesions on NSAID therapy

      • C. B. H. W. Lamers

      Pages 154-158

The contents of this book represent papers which were presented at the Third International Meeting on "Side-Effects of Anti-Inflammatory and Analgesic Drugs" which was held under the auspices of the University of Verona, Institute of Pharmacology in Verona on 8-11 May 1991. This meeting was held in conjunction with the 13th European Workshop on Inflammation and although publications from this part of the meeting are not published here (they appear in Agents and Actions), we were fortunate in having a group of people interested in inflammation from varying backgrounds. The success of the third meeting followed previous meetings held in Cambridge and Verona respectively and continue a tradition which has now become well established. The meeting brought together physicians, scientists and those concerned with the production and use of anti-inflammatory drugs to a very stimulating conference to discuss basic issues affecting all aspects of side-effects of anti-inflammatory and analgesic drugs as well as their detection and treatment. The meeting was held in the Auditorium of Glaxo Italy and we are very grateful to that company for use of their facilities as well as to the University of Verona, Institute of Pharmacology, for valuable secretarial and administrative help. The success of the conference would not have been possible without valuable financial assistance of the companies listed separately (under Acknowledgements) as well as to the organizers of the 13th European Workshop on Inflammation who collaborated with us.

• kidney
• liver
• research
• hepatology

• Department of Biomedical Sciences and Pathology, McMaster University Faculty of Health Sciences, Hamilton, Canada

  K. D. Rainsford

• Istituto of Farmacologia, Università di Verona, Verona, Italy

  G. P. Velo

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