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Neurotox ’91

Molecular Basis of Drug & Pesticide Action

  • Book
  • © 1992

Overview

Editors:
  1. I. R. Duce

    1. Department of Life Science, University of Nottingham, Nottingham, UK

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xxvii
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  2. Natural Products

    1. Front Matter

      Pages 1-1
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    2. Philanthotoxin-433 and Analogs, Noncompetitive Antagonists of Glutamate and Nicotinic Acetylcholine Receptors

      • Gary Chiles, Seok-Ki Choi, Amira Eldefrawi, Mohyee Eldefrawi, Shinji Fushiya, Robert Goodnow Jr et al.
      Pages 3-17

    3. Spider Neurotoxins as Tools for the Investigation of Glutamatergic Synaptic Transmission

      • L. G. Magazanik, S. M. Antonov, V. Yu. Bolshakov, I. M. Fedorova, S. A. Gapon
      Pages 19-31

    4. Probing Calcium Channels with Venom Toxins

      • Michael E. Adams, Vytautas P. Bindokas, Virginia J. Venema
      Pages 33-44

    5. Conus Peptides and Biotechnology

      • Baldomero M. Olivera, Lourdes J. Cruz, Richard A. Myers, David R. Hillyard, Jean Rivier, Jamie K. Scott
      Pages 45-55

    6. Natural and Synthetic Toxins at Insect Receptors and Ion Channels: the Search for Insecticide Leads and Target Sites

      • Jack A. Benson
      Pages 57-70

    7. Avermectins: Idiosyncratic Toxicity in a Subpopulation of Collie Dogs

      • J. M. Schaeffer, S. P. Rohrer, D. Cully, J. Arena
      Pages 71-76

  3. Molecular and Cellular Physiology of Insects and Nematodes

    1. Front Matter

      Pages 77-77
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    2. The GABA Activated Cl- Channel in Insects as Target for Insecticide Action: a Physiological Study

      • Harald C. von Keyserlingk, R. John Willis
      Pages 79-104

    3. Pharmacology of the Ascaris Nervous System

      • R. J. Walker, L. M. Colquhoun, H. R. Parri, R. G. Williams, L. Holden-Dye
      Pages 105-121

    4. Chemical Intercellular Signalling Mechanisms in the Nervous System of the Nematode Ascaris suum: Potential Sites of Actions of New Generations of Anthelmintic Drugs

      • Antony O. W. Stretton
      Pages 123-138

    5. The Peptidergic Neuron: Possible New Molecular Targets

      • Michael O’Shea, Richard C. Rayne
      Pages 139-151

  4. Applications of Molecular Biology

    1. Front Matter

      Pages 153-153
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    2. Cloning Nematode Acetylcholine Receptor Genes

      • James A. Lewis, John T. Fleming, David Bird
      Pages 155-164

    3. The Molecular Biology of Potassium Channels and Mutations that Alter the Selectivity of the Pore

      • Thomas L. Schwarz, Andrea J. Yool
      Pages 165-177

    4. FMRFamide-Related Peptides: Organisation and Expression of the Gene in the Snail Lymnaea

      • Julian F. Burke, Kerris Bright, Susan E. Saunders, Elaine Kellett, Paul R. Benjamin
      Pages 179-190

    5. Expression of Neurotransmitter Receptors in Insect Cells Using Baculovirus Vectors

      • Linda A. King, Allan E. Atkinson, Louis A. Obosi, Isabel Bermudez, David J. Beadle
      Pages 191-202

    6. Functional Expression in Xenopus Oocytes of Invertebrate Ligand-Gated Ion Channels

      • David B. Sattelle, Sarah C. R. Lummis, Howard A. Riina, John T. Fleming, Nicola M. Anthony, John Marshall
      Pages 203-219

  5. Molecular Structure

    1. Front Matter

      Pages 221-221
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Keywords

About this book

NEUROTOX '91 was the fourth meeting in a series which started in 1979. The '91 meeting, like its predecessors, was held under the patronage of the Society of Chemical Industry, and despite the unfortunate proximity of hostilities in the Arabian Gulf attracted a truly international mix of industrial and academic pesticide scientists. This volume contains the text of invited papers read at the meeting and presents the dramatic developments which so excited those who attended. The potential of molecular neurobiology for gaining knowledge of target sites for neurotoxicants is now starting to be realised. These studies, in conjunction with developments in molecular imaging and modelling, provide new oppor­ tunities for chemists and biologists to gain insights into molecular interactions underlying intoxication. Molecular techniques have also enabled rapid ad­ vances on a second front, where the cloning of genes controlling pesticide resistance should have a profound impact on our understanding of this commercially important problem. The understanding of molecular events will undoubtedly be vital in future developments in chemical control of pests; however, the value of understand­ ing the way in which the nervous system controls behaviour and how behaviour can be modified by chemicals of bath synthetic and natural origins was highlighted. Natural products and their synthetic analogues have continued to provide new and interesting molecules which are already proving their worth as tools for the neuroscientist and may offer leads for commercial synthesis.

Editors and Affiliations

  • Department of Life Science, University of Nottingham, Nottingham, UK

    I. R. Duce

Bibliographic Information

  • Book Title: Neurotox ’91

  • Book Subtitle: Molecular Basis of Drug & Pesticide Action

  • Editors: I. R. Duce

  • DOI: https://doi.org/10.1007/978-94-011-2898-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: SCI 1992

  • Hardcover ISBN: 978-1-85166-746-8Published: 31 July 1992

  • eBook ISBN: 978-94-011-2898-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXVIII, 362

  • Topics: Neurosciences, Pharmacology/Toxicology, Neurology

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