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Calcium Antagonists

Pharmacology and Clinical Research

  • Book
  • © 1993

Overview

Editors:
  1. T. Godfraind

    1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

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  2. R. Paoletti

    1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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  3. S. Govoni

    1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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  4. P. M. Vanhoutte

    1. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, USA

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Part of the book series: Medical Science Symposia Series (MSSS, volume 3)

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Table of contents (48 chapters)

  1. Front Matter

    Pages i-xxv
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  2. Calcium Channels, The Molecular Approach

    1. Structure-Function Studies of the Voltage-Dependent Calcium Channels

      • Olga Krizanova, Philippe Lory, Arnold Schwartz
      Pages 1-8

    2. Regulation of Calcium Channels By Protein Phosphorylation

      • M. M. Hosey, R. M. Brawley, C. F. Chang, L. M. Gutierrez, J. Ma, E. Rios et al.
      Pages 9-14

    3. Interactions of Lacidipine and other Calcium Channel Drugs with Biological Membranes: A Structural Model for Receptor/Drug Binding Utilizing the Membrane Bilayer

      • Leo G. Herbette, Giovanni Gaviraghi, Robert J. Dring, Lawrence J. Briggs, R. Preston Mason
      Pages 15-23

  3. Cardiovascular Applications of Calcium Antagonists: From Pathophysiology to Therapy

    1. Hypertension and Heart Failure

      1. Regulation of Calcium Channels in Vascular Smooth Muscle
        • Nicole Morel, Theophile Godfraind
        Pages 25-30
      2. Calcium and the Production of Endothelium-Derived Vasoactive Factors
        • V. B. Schini, T. Nagao, S. Illiano, P. M. Vanhoutte
        Pages 31-36
      3. Postnatal Development of Calcium Channels in Cardiac Muscle
        • M. Wibo, T. Godfraind
        Pages 37-42
      4. The Hemodynamic Effects of Calcium Antagonists under Pathological Conditions
        • P. A. van Zwieten
        Pages 43-48
      5. Calcium, Ischemia, and the Calcium Antagonists
        • Winifred G. Nayler
        Pages 49-58
      6. Multiple Organ Protection through Endothelial Cell Stabilization: A Mechanism of Action of Calcium Antagonists?
        • Fred De Clerck, Walter Janssens, Fons Verheyen
        Pages 59-63
      7. New Insight into the Vascular Properties of Lacidipine
        • G. Gaviraghi, T. Godfraind
        Pages 65-69
      8. Effect of Felodipine on Left Ventricular Performance in Conscious Dogs: Assessment by Left Ventricular Pressure-Volume Analysis
        • W. C. Little, C. P. Cheng
        Pages 71-76
      9. Lacidipine in the Treatment of Hypertension: Clinical Data
        • Giuseppe Mancia
        Pages 77-85
      10. Insights in the Cardioprotective Mechanism of the New Drug R56865
        • F. Verdonck, F. V. Bielen, L. Ver Donck, M. Borgers
        Pages 87-92
      11. Do the Differences Between Calcium Antagonists Matter When Treating Hypertension?
        • T. Morgan, A. Anderson
        Pages 93-98
      12. Effects of Lacidipine on Ischemic and Reperfused Myocardium
        • A. Boraso, A. Cargnoni, A. Maggi, R. Ferrari, O. Visioli
        Pages 99-106

    2. Atherosclerosis

      1. Atherogenic Activity caused by Excess Membrane Cholesterol in Arterial Smooth Muscle: Role of Calcium Channels
        • Thomas N. Tulenko, R. Preston Mason, Meng Chen, Hiromi Tasaki, Daniel Rock, David Stepp
        Pages 107-115
      2. Understanding the Initiating Factors in Atherosclerosis: Implications for Intervention
        • Winifred G. Nayler
        Pages 117-124
      3. Calcium Antagonists and Lipid-Lowering Agents in the Protection of the Arterial Wall
        • R. Paoletti, M. Raiteri, M. Soma, F. Bernini
        Pages 125-132
      4. Calcium Channel Blockers as Agents for the Treatment of Atherosclerosis
        • Philip D. Henry, Moises Bucay
        Pages 133-138
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Keywords

About this book

Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades.
As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally.
This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.

Editors and Affiliations

  • Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  • Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti, S. Govoni

  • Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, USA

    P. M. Vanhoutte

Bibliographic Information

  • Book Title: Calcium Antagonists

  • Book Subtitle: Pharmacology and Clinical Research

  • Editors: T. Godfraind, R. Paoletti, S. Govoni, P. M. Vanhoutte

  • Series Title: Medical Science Symposia Series

  • DOI: https://doi.org/10.1007/978-94-011-1725-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1993

  • Hardcover ISBN: 978-0-7923-2259-7Published: 31 May 1993

  • Softcover ISBN: 978-94-010-4756-2Published: 22 January 2013

  • eBook ISBN: 978-94-011-1725-8Published: 14 March 2013

  • Series ISSN: 0928-9550

  • Edition Number: 1

  • Number of Pages: XXV, 381

  • Topics: Cardiology, Pharmacology/Toxicology

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