Drugs Affecting Lipid Metabolism

1. Front Matter

   Pages i-xx

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2. Regression of Human Aortic Fatty Streaks of Early Life

   • M. Daria Haust

   Pages 1-8

3. Serum Cholesterol as a Risk Factor: Effects of Gender and Age

   • Frederick H. Epstein

   Pages 9-13

4. Influence of Atherogenic Lipoproteins on The Thrombotic Potential of Endothelial Cells

   • Marina Camera, Susanna Colli, Luigi Sironi, Livia Prati, Cristina Banfi, Luciana Mussoni et al.

   Pages 15-22

5. Plurimetabolic syndrome or syndrome X. Is it a real syndrome?

   • Enzo Manzato, Romano Nosadini, Gaetano Crepaldi

   Pages 23-27

6. Three Liver-Enriched Transcription Factors: HNF-1, C/EBP, and Protein II are Required to Enhance Transcription of the Human Apolipoprotein B Gene

   • Alan R. Brooks, Beatriz Levy-Wilson

   Pages 29-44

7. Structure-Function Relationships of Apolipoprotein B-100

   • Lawrence Chan

   Pages 45-47

8. Contribution of Helix-Helix Interactions to the Stability of Apolipoprotein-Lipid Complexes

   • B. Vanloo, M. De Pauw, L. Lins, R. Brasseur, J-M. Ruysschaert, M. Rosseneu

   Pages 49-56

9. Oxidatively Modified LDL and Atherosclerosis

   • Daniel Steinberg

   Pages 57-68

10. Postprandial Hyperlipidemia and Coronary Artery Disease

    • Josef R. Patsch

    Pages 69-74

11. Genetic Factors Affecting Lipoprotein Metabolism

    • Kåre Berg

    Pages 75-82

12. Lipoprotein Assembly: A Potential Target for Drugs Affecting Lipid Metabolism

    • Roger A. Davis

    Pages 83-87

13. Structural Features that Determine the Functional Properties of the Loop Region of Human Lipoprotein Lipase

    • Roger D. Knapp, Fabrizia Faustinella, Louis C. Smith, Lawrence Chan

    Pages 89-96

14. Molecular Genetics of Lipoprotein Lipase Deficiency

    • Yuanhong Ma, Michael R. Hayden

    Pages 97-100

15. A New Case of Lipoprotein Lipase Deficiency

    • A. Capurso, G. Pepe, G. Chimienti, F. Resta, M. Lovecchio, A. M. Colacicco

    Pages 101-106

16. Modulation of Triglyceride Metabolism by Diet and Drugs

    • Patricia Pace, Roger D. Knapp, Peter H. Jones, Henry J. Pownall, Antonio M. Gotto Jr.

    Pages 107-113

17. Drugs Affecting Reverse Cholesterol Transport

    • G. Chiesa, L. Calabresi, G. Franceschini, C. R. Sirtori

    Pages 115-120

18. High Density Lipoproteins: Function in Reverse Cholesterol Transport and Maintenance of Cellular Integrity

    • K. J. Lackner, G. Schmitz

    Pages 121-129

19. The Expression and Regulation of Cholesterol 7α-Hydroxylase

    • W. G. Karam, T. P. Yang, D. P. Wang, J. Y. L. Chiang

    Pages 131-138

20. Cholesterol Metabolism in Normo and Genetically Hyperlipidemic Rats in Aging

    • M. Cancellieri, S. Baratte’, E. De Fabiani, E. Bosisio, G. Galli

    Pages 139-143

A great deal of experimental, clinical and epidemiological data have been gathered to confirm the strict and causal correlation between plasma lipoproteins and coronary heart disease. However, as usually happens in research, many more interesting issues are being studied, opening new fields of research for the future. These new advances, together with the combined efforts of cell biologists and lipoprotein chemists, have set the pace for an exciting period of research and clinical applications of diets and drugs affecting plasma and cell lipids. This volume, which includes the work of many of the leading world labortories, represents an authoritative and up-to-date appraisal of the status of the art and a stimulus to future research at the laboratory and clinical level in a fascinating area of clinical and preventive medicine.

• Lipoprotein
• atherosclerosis
• heart
• lipide
• metabolism
• research
• thrombosis

• Istituto di Scienze Farmacologiche, Università di Milano, Milano, Italy

  A. L. Catapano, Rodolfo Paoletti

• Department of Medicine, Baylor College of Medicine, Houston, USA

  A. M. Gotto

• Department of Medicine, The Methodist Hospital, Houston, USA

  Louis C. Smith

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