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Immunology of Liver Disease

  • Book
  • © 1994

Overview

Editors:
  1. H. C. Thomas

    1. Department of Medicine, St Mary’s Hospital Medical School, London, UK

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  2. J. Waters

    1. Department of Medicine, St Mary’s Hospital Medical School, London, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Immunology and Medicine (IMME, volume 21)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. Immunopathology and Virus Infections

    • B. A. Askonas
    Pages 1-9

  3. Immunopathology of Hepatitis A and Hepatitis E Virus Infections

    • E. A. Brown, J. Ticehurst, S. M. Lemon
    Pages 11-37

  4. Immunobiology of Hepatitis B and D Virus Infections

    • M. U. Mondelli, F. Negro
    Pages 39-55

  5. Hepatitis C Virus: Infection and Immunity

    • J. Monjardino
    Pages 57-67

  6. Human Hepatoma Associated Antigens: Opportunities for Immunotherapy

    • D. Shouval, R. Adler
    Pages 69-83

  7. Mechanisms of Autoimmunity

    • M. Peakman, D. Vergani, A. L. W. F. Eddleston
    Pages 85-109

  8. Autoantibodies and their Cytoplasmic Antigens in Autoimmune Chronic Active Hepatitis

    • M. P. Manns, K. -H. Meyer Zum Büschenfelde
    Pages 111-120

  9. Primary Biliary Cirrhosis

    • D. E. J. Jones, W. L. Gregory, M. F. Bassendine
    Pages 121-143

  10. The Immunology of Primary Sclerosing Cholangitis

    • R. W. Chapman
    Pages 145-155

  11. Immune Mechanisms in Alcoholic Liver Disease

    • R. D. Goldin, N. C. A. Hunt
    Pages 157-172

  12. Immune-Mediated Drug Hepatotoxicity

    • J. G. Kenna
    Pages 173-200

  13. Back Matter

    Pages 201-209
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Keywords

About this book

The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.

Editors and Affiliations

  • Department of Medicine, St Mary’s Hospital Medical School, London, UK

    H. C. Thomas, J. Waters

Bibliographic Information

  • Book Title: Immunology of Liver Disease

  • Editors: H. C. Thomas, J. Waters

  • Series Title: Immunology and Medicine

  • DOI: https://doi.org/10.1007/978-94-011-1428-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1994

  • Hardcover ISBN: 978-0-7923-8975-0Published: 31 December 1993

  • Softcover ISBN: 978-94-010-4625-1Published: 27 September 2012

  • eBook ISBN: 978-94-011-1428-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 209

  • Topics: Immunology, Hepatology

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