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Multiple Drug Resistance in Cancer

Cellular, Molecular and Clinical Approaches

  • Book
  • © 1994

Overview

Editors:
  1. Martin Clynes

    1. National Cell & Tissue Culture Center/Bioresearch Ireland, Dublin City University, Glasnevin, Dublin, Ireland

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-viii
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  2. P-glycoprotein structure and evolutionary homologies

    • James M. Croop
    Pages 1-32

  3. Molecular analysis of the multidrug transporter

    • Ursula A. Germann
    Pages 33-62

  4. Molecular cytogenetics of multiple drug resistance

    • Patricia V. Schoenlein
    Pages 63-89

  5. Antibodies in the study of multiple drug resistance

    • Yuji Heike, Takashi Tsuruo
    Pages 91-107

  6. Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug

    • Melvin S. Center
    Pages 109-125

  7. Topoisomerase I in multiple drug resistance

    • Augusto Pessina
    Pages 127-135

  8. Topoisomerase II in multiple drug resistance

    • Glenn A. Hofmann, Michael R. Mattern
    Pages 137-154

  9. Glutathione-related enzymes, glutathione and multidrug resistance

    • Jeffrey A. Moscow, Katharine H. Dixon
    Pages 155-170

  10. Pharmacologic circumvention of multidrug resistance

    • James M. Ford, William N. Hait
    Pages 171-212

  11. Multidrug resistance (MDR) genes in haematological malignancies

    • K. Nooter, P. Sonneveld
    Pages 213-230

  12. Human cell lines as models for multidrug resistance in solid tumours

    • Martin Clynes, Mary Heenan, Keara Hall
    Pages 231-256

  13. Studies on low-level MDR cells

    • G. Belvedere, E. Dolfini
    Pages 257-264

  14. Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro

    • Bridget T. Hill
    Pages 265-288

  15. The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells

    • Lorraine O’Driscoll, Carmel Daly, Mohamad Saleh, Martin Clynes
    Pages 289-314

  16. Mathematical models for multidrug resistance and its reversal

    • Seth Michelson
    Pages 315-324

  17. The biology of radioresistance: similarities, differences and interactions with drug resistance

    • Simon N. Powell, Edward H. Abraham
    Pages 325-345

  18. Kinetic resistance to anticancer agents

    • Marie-Thérèse Dimanche-Boitrel, Carmen Garrido, Bruno Chauffert
    Pages 347-356

  19. Cytochromes P450 and drug resistance

    • Johannes Doehmer, Arnold R. Goeptar, Nico P. E. Vermeulen
    Pages 357-366

  20. Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors

    • Susan McDonnell, Barbara Fingleton
    Pages 367-384
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Keywords

About this book

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

Editors and Affiliations

  • National Cell & Tissue Culture Center/Bioresearch Ireland, Dublin City University, Glasnevin, Dublin, Ireland

    Martin Clynes

Bibliographic Information

  • Book Title: Multiple Drug Resistance in Cancer

  • Book Subtitle: Cellular, Molecular and Clinical Approaches

  • Editors: Martin Clynes

  • DOI: https://doi.org/10.1007/978-94-011-0826-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1994

  • Hardcover ISBN: 978-0-7923-2669-4Published: 28 February 1994

  • Softcover ISBN: 978-94-010-4355-7Published: 14 October 2012

  • eBook ISBN: 978-94-011-0826-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 393

  • Topics: Oncology, Cancer Research, Biochemistry, general, Pharmacy, Pharmacology/Toxicology

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