Side-Effects of Anti-Inflammatory Drugs

Gastrointestinal Tract (Experimental Aspects)

1. Front Matter

   Pages 1-1

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2. Mechanisms of gastric contrasted with intestinal damage by non-steroidal anti-inflammatory drugs

   • K. D. Rainsford

   Pages 3-28

3. The enterohepatic circulation of some anti-inflammatory drugs may cause intestinal ulcerations

   • K. Brune, B. Nürnberg, I. Szelenyi, H. Vergin

   Pages 29-39

4. Limitations of laboratory models in predicting gastrointestinal toleration of oxicams and other anti-inflammatory drugs

   • E. H. Wiseman, Y. Noguchi

   Pages 41-54

5. Why are non-steroidal anti-inflammatory drugs so gastrotoxic, even when given orally as solubilized salt formulations or parenterally?

   • M. W. Whitehouse, K. D. Rainsford

   Pages 55-65

6. Early and late phases in the formation by anti-inflammatory drugs of intestinal lesions in rats

   • P. Del Soldato, D. Foschi, G. Benoni, G. P. Velo

   Pages 67-81

7. Role of intestinal microflora in maintaining indomethacin-induced intestinal lesions in rats

   • G. Benoni, P. Del Soldato, L. Cuzzolin, G. P. Velo

   Pages 83-87

8. Comparison of gastric mucosal damage and prostaglandin formation in arthritis patients treated with carprofen and ibuprofen

   • S. J. Konturek, J. Oleksy, E. Zielonka

   Pages 89-96

9. Inhibition of prostanoid synthesis by anti-inflammatory drugs in human gastric mucosa

   • P. O. Collins, I. A. Tavares, A. Bennett

   Pages 97-100

10. Leukotriene formation in the gastrointestinal tract and effects of anti-inflammatory drugs

    • K. W. Dreyling, U. Hoppe, A. Kleine, W. Kozuschek, B. M. Peskar

    Pages 101-112

11. Evidence for sulphydryl-sensitive process in the mechanisms of acute gastric mucosal injury and defence

    • E. Ezer

    Pages 113-121

12. Experimental and clinical studies on the prevention of aspirin-induced gastric damage by “cytoprotective” drugs

    • S. J. Konturek, N. Kwiecien, T. Radecki, J. Oleksy

    Pages 123-132

13. Both E Prostaglandins and prolonged indomethacin treatment exert trophic effects on the gastric mucosa

    • F. Halter, A. Baumgartner, L. Varga, H. R. Koelz

    Pages 133-142

14. Gastrointestinal side-effects of prostaglandins

    • E. J. S. Boyd, K. G. Wormsley

    Pages 143-149

15. Investigation of auranofin-induced diarrhoea

    • R. Behrens, M. Deveraux, B. Hazleman, K. Szaz, J. Calvin, G. Neale

    Pages 151-158

16. Pyrido-pyrimidines — with analgesic and anti-inflammatory activity — inhibit the gastrointestinal mucosal damage induced by different prostaglandin synthesis inhibitors

    • K. Gyires, J. Knoll

    Pages 159-160

17. Al(OH)3 inhibits aspirin-induced gastric lesions in cats with Heidenhain pouch

    • H. Beck, H. Engler, I. Szelenyi

    Pages 161-162

18. Polyene phosphatidylcholine: an inhibitor of NSAID gastric toxicity which increases impaired mucosal PGE2 synthesis

    • S. Leyck, A. M. Huther, M. J. Parnham

    Pages 163-164

19. Prostaglandins prevent red streaks in rat gastric mucosa caused by intravenous aspirin but not by salicylate

    • P. H. Rowe

    Pages 165-166