Side-Effects of Anti-Inflammatory Drugs

1. Front Matter

   Pages i-xxv

   PDF

2. Clinical and Epidemiological Aspects

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction and historical aspects of the side-effects of anti-inflammatory analgesic drugs

      • K. D. Rainsford

      Pages 3-26

   3. Epidemiology in the United Kingdom of adverse drug reactions from non-steroidal anti-inflammatory drugs

      • J. C. P. Weber

      Pages 27-35

   4. Assessment of adverse reactions to NSAIDs: pre- and post- marketing

      • E. F. Barker

      Pages 37-46

   5. Incidence of serious side-effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USA

      • H. Jick

      Pages 47-53

   6. Trends and patterns in adverse drug reactions to non-steroidal anti-inflammatory drugs reported in Sweden

      • B. E. Wiholm, M. Myrhed, E. Ekman

      Pages 55-72

   7. Rare adverse reactions to non-steroidal anti-inflammatory drugs

      • W. M. O’Brien

      Pages 73-98

   8. Pyrazoione-induced agranulocytosis: an epidemiological evaluation

      • Micha Levy

      Pages 99-104

   9. Potential biases influencing interpretation of data from worldwide spontaneous ADR reports

      • A. J. Gordon, R. Sachs

      Pages 105-110

   10. Prescription-event monitoring of five non-steroidal anti-inflammatory drugs

       • W. H. W. Inman, N. S. B. Rawson

       Pages 111-124

   11. Side-effects of non-steroidal anti-inflammatory drugs in children with juvenile rheumatoid arthritis

       • T. K. Kvien, H. M. Høyeraal, B. Sandstad, E. Kåss

       Pages 125-135

   12. Non-steroidal anti-inflammatories: outpatient audit of patient preferences and side-effects in different diseases

       • N. L. Cox, S. M. Doherty

       Pages 137-150

   13. Non-steroidal anti-inflammatories in the elderly

       • P. P. Lamy

       Pages 151-172

   14. Ibuprofen overdose — the first year following over-the-counter release

       • S. Perry, P. Streete, G. N. Volans

       Pages 173-175

3. Drug Interactions and Drug Metabolism

   1. Front Matter

      Pages 177-177

      PDF

   2. Drug interactions between the anti-inflammatory drugs and with other agents

      • P. F. D’Arcy, J. C. McElnay

      Pages 179-193

   3. Interaction between non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors in man

      • G. P. Velo, P. Minuz, E. Arosio, M. G. Capuzzo, G. Covi, A. Lechi

      Pages 195-201

   4. Responders and non-responders to NSAI drug interactions — a neglected problem?

      • F. Sörgel, R. Koob, M. Hemmerlein, J. Braun, E. Lang

      Pages 203-215

   5. Biological implications of the metabolic chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs

      • J. Caldwell, A. J. Hutt

      Pages 217-228

These two volumes contain the proceedings of a 3 day international meeting held at the University of Cambidge and Queens' College Cambridge from 31st July to 2nd August 1985 on the Side-Effects of Anti-Inflammatory Analgesic Drugs. The first meeting was held in Verona, (Italy) in 1982 and the organisers felt that, with a number of recent developments including the withdrawal of a num­ ber of new anti-inflammatory drugs, and concern being expressed in the lay and specialist medical press and other media about the safety of these drugs, that it was appropriate to have a second such meeting. The meeting was attended by some 300 delegates and the dis­ cussion focussed most intently on the recent issues, e. g. the value of adverse drug reaction reporting of the non-steroidal anti­ inflammatory (NSAI) drugs, certain side-effects associated with particular NSAI drugs, the predictive value of animal models etc. Organising a meeting de novo without outside help would not have been possible without the immensely valuable help given en­ thusiastically by people and financial assistance given most generously by those pharmaceutical companies listed below. These financial contributions were given despite current economic dif­ ficulties and moves to restrict the proportion of profits towards educational activities.

• Arthritis
• drug
• inflammation
• metabolism
• pharmacokinetics
• pharmacology
• rheumatoid arthritis
• toxicology

• Department of Pharmacology, University of Cambridge, Cambridge, UK

  K. D. Rainsford

• Strangeways Research Laboratory, Cambridge, UK

  K. D. Rainsford

• Institute of Pharmacology, University of Verona, Verona, Italy

  G. P. Velo

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