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Isoenzymes

  • Book
  • © 1980

Overview

Authors:
  1. C. C. Rider

    1. Royal Holloway College, University of London, UK

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  2. C. B. Taylor

    1. University of Sheffield, UK

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Part of the book series: Outline Studies in Biology (OSB)

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Table of contents (8 chapters)

  1. Front Matter

    Pages 1-6
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  2. Introduction

    • C. C. Rider, C. B. Taylor
    Pages 7-7

  3. Structural aspects of isoenzymes

    • C. C. Rider, C. B. Taylor
    Pages 8-17

  4. Isoenzymes in genetics and evolution

    • C. C. Rider, C. B. Taylor
    Pages 18-31

  5. Isoenzymes in development and differentiation

    • C. C. Rider, C. B. Taylor
    Pages 32-46

  6. Isoenzymes in metabolic regulation

    • C. C. Rider, C. B. Taylor
    Pages 47-54

  7. Isoenzymes in cancer

    • C. C. Rider, C. B. Taylor
    Pages 55-64

  8. Isoenzymes in diagnosis and disease

    • C. C. Rider, C. B. Taylor
    Pages 65-74

  9. Separation and determination of isoenzymes

    • C. C. Rider, C. B. Taylor
    Pages 75-78

  10. Back Matter

    Pages 79-80
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Keywords

About this book

Isoenzymes were 'discovered' 20 years ago and were at first regarded as interesting but rare occurrences. Since then a wealth of information on enzyme heterogeneity has accrued and it now seems likely that at least half of all enzymes exist as isoenzymes. This is important in many areas of biological and medical science. Thus isoenzyme studies have provided the main experimental substance for the neutral drift controversy in genetics and evolution; they have greatly extended our understanding of metabolic regulation not only in animals but also in bacteria and plants; their existence has made available a multitude of highly sensitive markers for the study of differentiation and development, as well as providing indices of aberrant gene expression in carcinogenesis and other pathological processes. Iso­ enzymes are also being used increasingly in diagnostic clinical bio­ chemistry. It is surprising that this phenomenon which affects such a high pro­ portion of enzymes and is clearly important in biochemistry should receive such scant attention in the standard textbooks of that subject, the formal treatment of isoenzymology in these rarely exceeding one or two pages. This may be because the 'pure biochemist' has tended to regard variation in enzyme properties between tissues more as an unwanted complication than as a potential source of insight into diversity of biological function.

Authors and Affiliations

  • Royal Holloway College, University of London, UK

    C. C. Rider

  • University of Sheffield, UK

    C. B. Taylor

Bibliographic Information

  • Book Title: Isoenzymes

  • Authors: C. C. Rider, C. B. Taylor

  • Series Title: Outline Studies in Biology

  • DOI: https://doi.org/10.1007/978-94-010-9447-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: C. C. Rider, C. B. Taylor 1980

  • Softcover ISBN: 978-0-412-15640-3Published: 30 October 1980

  • eBook ISBN: 978-94-010-9447-4Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: 80

  • Number of Illustrations: 16 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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