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Influence of Tumor Development on the Host

  • Book
  • © 1989

Overview

Editors:
  1. Lance A. Liotta

    1. Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, USA

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Part of the book series: Cancer Growth and Progression (CAGP, volume 3)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
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  2. Aspects of the primary tumor

    1. Stroma, Generally a Non-Neoplastic Structure of the Tumor

      • H. E. Kaiser
      Pages 1-8

    2. Malignant Transformation

      • H. E. Kaiser
      Pages 9-17

    3. Metabolic Changes in Malignancy

      • Freddie A. Hoffman
      Pages 18-27

    4. Ion Deregulation, Cell Injury and Tumor Promotion

      • Benjamin F. Trump, Irene K. Berezesky, Kookmin M. Kim
      Pages 28-34

    5. Multiple Primary Neoplasms: Role of Autopsy. Selected Sites, with Emphasis on Japan

      • Shaw Watanabe
      Pages 35-39

    6. Multiple Primary Neoplasms

      • H. E. Kaiser
      Pages 40-57

  3. Shared aspects of primary and secondary tumors

    1. Mechanisms of Cancer Invasion and Metastases

      • Lance A. Liotta
      Pages 58-71

    2. Extracellular Matrix and Its Enzymatic Degradation in Tumor Invasion

      • Karl Tryggvason
      Pages 72-83

    3. Cell Surfaces and Secondary Tumor Formation

      • Garth L. Nicolson
      Pages 84-96

    4. DNA Transfection, Genetic Instability, and Metastasis

      • Ann F. Chambers
      Pages 97-102

    5. The Contribution of DNA Methylation to the Generation of Tumor Cell Heterogeneity, Tumor Progression and Metastasis

      • Robert G. Liteplo, Robert S. Kerbel, Philip Frost
      Pages 103-111

    6. Neoplastic Progression by Somatic Cell Fusion

      • Patrick De Baetselier
      Pages 112-120

    7. Cell Junctional Alterations in Cancer

      • Bendicht U. Pauli, Ronald S. Weinstein
      Pages 121-132

    8. Cytogenetic Studies in Neoplasia (Human and Animal): Implications Prognosis, and Treatment

      • Jacqueline Whang-Peng, Turid Knutsen
      Pages 133-175

    9. Cancer Cachexia

      • S. D. Morrison
      Pages 176-213

    10. Paraneoplastic Syndromes

      • Robert A. Nagourney, Paul V. Woolley
      Pages 214-227

  4. Back Matter

    Pages 228-240
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Keywords

About this book

Recent experimental evidence has made it increasingly clear In particular, this volume reviews the discrete steps involved that the properties of invasive, malignant cells during tumor in metastatic invasion: the interaction of invasive tumor cells development substantially impact on the host. This is under­ with extracellular matrices, the basement membrane, attach­ scored by a variety of biochemical properties of tumor cells ment to extracellular matrices, local proteolytic degradation during their differentiation and metastatic dissemination. of matrices, and the locomotion of invasive tumor cells These properties can be analyzed at different stages of tumor through such areas of localized degradation. The critical growth and progression and this volume explores the role of the cell surface in secondary tumor formation is characteristics of primary tumors as well as the shared reviewed as are important advances in the molecular biology characteristics of both primary and secondary tumors. of metastasis initiation and maintenance. Recent advances The primary tumor comes into existence following in the role of DNA methylation in the generation of tumor preneoplastic biochemical and cellular events that ultimate­ cell heterogeneity and tumor progression are also critically ly result in malignant transformation. Various aspects of summarized. Chapters in this volume also review molecular metabolism, predetermined by nutritional status, often play aspects of metastatic progression, and the use of the tech­ a basic role. Obesity, for example, is cancer-promoting. Cell nologies of DNA transfection and somatic cell fusion in the surface carbohydrates, cytoskeletal proteins, glycoproteins, exploration of molecular aspects of metastatic progression.

Reviews

`... the present volume offers a wealth of detailed information of great interest to pathologists to be used in basic research as well as in his clinical activities.'

Editors and Affiliations

  • Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, USA

    Lance A. Liotta

Bibliographic Information

  • Book Title: Influence of Tumor Development on the Host

  • Editors: Lance A. Liotta

  • Series Title: Cancer Growth and Progression

  • DOI: https://doi.org/10.1007/978-94-009-2528-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1989

  • Hardcover ISBN: 978-0-89838-992-0Published: 31 December 1988

  • eBook ISBN: 978-94-009-2528-1Published: 06 December 2012

  • Series ISSN: 1871-3238

  • Edition Number: 1

  • Number of Pages: X, 240

  • Topics: Oncology, Pathology, Veterinary Medicine/Veterinary Science

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