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Starling’s Law of The Heart Revisited

  • Book
  • © 1988

Overview

Editors:
  1. H. E. D. J. Keurs

    1. Department of Medical Physiology, Faculty of Medicine, Health Science Centre, University of Calgary, Calgary, Canada

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  2. M. I. M. Noble

    1. King Edward VII Hospital, West Susex, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 89)

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Table of contents (10 chapters)

  1. Front Matter

    Pages I-XV
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  2. The Contribution of Myofibrillar Properties to the Sarcomere Length-Force Relationship of Cardiac Muscle

    • J. C. Kentish, H. E. D. J. Ter Keurs, D. G. Allen
    Pages 1-17

  3. The Mechanism of the Length-Tension Relation in Cardiac Muscle of Rana Catesbeiana

    • Tatsuo Iwazumi
    Pages 18-27

  4. Intracellular Calcium Concentration Following Length Changes in Mammalian Cardiac Muscle

    • D. G. Allen, G. L. Smith, C. G. Nichols
    Pages 28-42

  5. Some Dynamic Effects of Length and Isotonic Motion on Cardiac Sarcomere Shortening

    • John W. Krueger, Takao Okada
    Pages 43-59

  6. The Relation Between Contraction Dynamics and the Intracellular Calcium Transient in Mammalian Cardiac Muscle

    • Philippe R. Housmans
    Pages 60-66

  7. The Effects of Sarcomere Length on Force and Velocity of Shortening in Cardiac Muscle

    • H. E. D. J. ter Keurs, B. Wohlfart, L. Ricciardi, J. J. J. Bucx
    Pages 67-79

  8. Similarity and Dissimilarity Between Muscle Force-Length Relationship and Ventricular Pressure-Volume Relationship

    • K. Sagawa, W. C. Hunter, W. L. Maughan, D. Burkoff, D. Yue
    Pages 80-93

  9. The Importance of the Geometry of the Heart to the Pump

    • T. Arts, R. S. Reneman
    Pages 94-111

  10. Cardiac Pump Function and Ventricular Dimensions

    • G. Elzinga, G. J. Van Der Horn, N. Westerhof
    Pages 112-122

  11. The Pressure—Volume Relationship of the Intact Heart

    • Mark I. M. Noble
    Pages 123-139

  12. Back Matter

    Pages 140-145
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Keywords

About this book

H. E. D. J. TER KEURS & M. I. M. NOBLE The "Starling's Law of the Heart" and "The Frank-Starling Mechanism" have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper­ iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela­ tionship which depends directly on the force-length relationship of the 2 sarcomeres. Starling ,3 studied cardiac shortening as manifest by cardiac output and its relationship to end-diastolic conditions as manifest by right atrial pressure. Thus he was studying the ability of cardiac muscle to shorten more at a given load from a greater initial length. Starling in the promulga­ 4 tions of his law implied a common mechanism for these two phenomena and spoke of the "energy liberated" being a function of initial muscle fiber length. However, there has been much confusion about the interrelationship between the two different aspects studied by Frank and Starling. The 1960s saw the era of isolated cardiac muscle mechanics, beginning with 5 the paper of Abbott and Mommaerts. Whole muscle length-tension relations were equated with sarcomere-length-tension relations by fixation of muscle at a particular point on the curve and determination of sarcomere length by electronmicroscopy.

Editors and Affiliations

  • Department of Medical Physiology, Faculty of Medicine, Health Science Centre, University of Calgary, Calgary, Canada

    H. E. D. J. Keurs

  • King Edward VII Hospital, West Susex, UK

    M. I. M. Noble

Bibliographic Information

  • Book Title: Starling’s Law of The Heart Revisited

  • Editors: H. E. D. J. Keurs, M. I. M. Noble

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-009-1313-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1988

  • Softcover ISBN: 978-94-010-7084-3Published: 26 September 2011

  • eBook ISBN: 978-94-009-1313-4Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: 168

  • Topics: Cardiology

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