Eicosanoids and the Gastrointestinal Tract

1. Front Matter

   Pages i-x

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2. The role of eicosanoids in inflammatory bowel disease

   • M. Ligumsky, D. Rachmilewitz

   Pages 1-11

3. Laboratory methods for studying the role of eicosanoids in inflammatory bowel disease

   • N. K. Boughton-Smith, B. J. R. Whittle

   Pages 12-45

4. Clinical uses of prostaglandins in peptic ulcer disease

   • S. J. Konturek

   Pages 46-74

5. Animal models for studying the role of eicosanoids in peptic ulcer disease

   • S. Szabo, C. H. Cho

   Pages 75-102

6. Protection against mucosal damage: Mechanism of action of eicosanoids

   • A. Robert

   Pages 103-110

7. Interplay between anti-inflammatory drugs and eicosanoids in gastrointestinal damage

   • K. D. Rainsford

   Pages 111-128

8. Alkaline secretion by the stomach and intestine: Effects of eicosanoids and anti-inflammatory drugs

   • A. Aly, G. Flemström

   Pages 129-144

9. Eicosanoids and gastrointestinal motility

   • P. K. Moore

   Pages 145-162

10. Effect of eicosanoids on gastrointestinal blood flow and microcirculation

    • G. Pihan, S. Szabo

    Pages 163-194

11. The gastroduodenal mucus barrier and the place of eicosanoids

    • A. Allen, A. Garner, A. C. Hunter, J. P. Keogh

    Pages 195-213

12. Back Matter

    Pages 215-219

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The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renaL cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series,AdvancesinEicosanoidResearch, reflects the current understanding of prostaglandins, thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the Series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr. Michael Brewis and the staff at MTP Press.

• gastrointestinal tract

• Clinical Pharmacology Group Medical Faculty, University of Southampton, UK

  Keith Hillier

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