Overview
- Editors:
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Alastair Strain
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Anne Mae Diehl
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Table of contents (25 chapters)
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Molecular and Cellular Analysis of Liver Growth
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- Nancy L. R. Bucher, Stephen R. Farmer
Pages 3-27
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- William B. Coleman, Joe W. Grisham
Pages 50-99
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- Eric Santoni-Rugiu, Snorri S. Thorgeirsson
Pages 100-142
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- Bonnie Burgess-Beusse, Humberto E. Soriano, Gretchen J. Darlington
Pages 143-162
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- Kenji Fujiwara, Sumiko Nagoshi
Pages 163-182
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Growth Factors
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Front Matter
Pages 183-183
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- William E. Russell, Robert S. Carver
Pages 185-218
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- Mikio Kan, Wallace L. McKeehan
Pages 240-260
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- Raymond N. DuBois, David Myers, R. Daniel Beauchamp
Pages 261-282
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- Giuliano Ramadori, Thomas Armbrust
Pages 283-294
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Signaling Events
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Front Matter
Pages 295-295
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- J. K. Westwick, D. A. Brenner
Pages 297-310
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- Janeen H. Trembley, Betsy T. Kren, Clifford J. Steer
Pages 311-365
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- Jan B. Hoek, Emanuel Rubin
Pages 366-401
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Biology of the Extracellular Matrix and Non-Parenchymal Cells
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Front Matter
Pages 403-403
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About this book
Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
