Helicobacter pylori

1. Front Matter

   Pages i-xx

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2. Helicobacter pylori - the organism

   1. Front Matter

      Pages 1-1

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3. Helicobacter pylori - the organism

   1. New Helicobacter species

      • A. Lee, B. Robertson

      Pages 3-12

   2. The origin of virulence in type I strains of Helicobacter pylori

      • A. Covacci, S. Censini, C. Lange, M. Marchetti, S. Guidotti, M. Stein et al.

      Pages 13-18

   3. vacA polymorphism

      • J. C. Atherton

      Pages 19-26

   4. The interaction of cag ⁺ Helicobacter pylori strains with their hosts

      • M. J. Blaser

      Pages 27-32

   5. Molecular mimicry between Helicobacter pylori and the host

      • B. J. Appelmelk, S. Straver, T. Verboom, E. J. Kuipers, D. Claeys, G. Faller et al.

      Pages 33-42

   6. Considerations of virulence by Helicobacter pylori

      • M. J. Blaser

      Pages 43-48

4. Helicobacter pylori — transmission

   1. Front Matter

      Pages 49-49

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5. Helicobacter pylori — transmission

   1. The faecal-oral route - a critical look

      • F. Mégraud, N. Broutet

      Pages 51-57

   2. Helicobacter pylori: oro-oral, orogastric transmission: a critical look at the evidence

      • E. Duggan, R. P. H. Logan

      Pages 58-67

   3. Vectors for the transmission of Helicobacter pylori

      • D. R. Cave, P. Grübel, L. Huang

      Pages 68-74

6. Helicobacter pylori — inflammation

   1. Front Matter

      Pages 75-75

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7. Helicobacter pylori — inflammation

   1. The host cell response to Helicobacter pylori attachment

      • L. S. Tompkins, E. Segal, S. Falkow

      Pages 77-83

   2. Changes in intracellular signaling following Helicobacter pylori infection of gastric epithelial cells

      • N. L. Jones, P. M. Sherman

      Pages 84-89

   3. Helicobacter pylori – interactions with phagocytes

      • M. Chmiela, B. Paziak-Domanska, S. Hirmo, W. Rudnicka, M. Utt, T. Wadström

      Pages 90-100

   4. Th1/Th2 lymphocyte responses in Helicobacter infections

      • J. G. Nedrud, M. Mohammadi, T. Blanchard, R. Redline, S. J. Czinn

      Pages 101-109

   5. Epithelial cell turnover and apoptosis

      • S. F. Moss

      Pages 110-122

   6. Cytokine-enhanced, Helicobacter pylori-induced, epithelial cell apoptosis

      • P. B. Ernst, V. E. Reyes, X. -J. Fan, S. E. Crowe

      Pages 123-130

8. Helicobacter pylori - functional secretory and motor disturbances

   1. Front Matter

      Pages 131-131

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The explosion of new information on Helicobacter pylori-related disease, both in the basic sciences and in clinical medicine, has continued to progress at an unprecedented pace. In many instances H. pylori infection, both in man and in the laboratory animal, has become a model to investigate fundamental biological issues such as micro-organism-host interactions, intracellular signalling, development of mucosal atrophy, mechanism of microbial resistance, disease modifying factors etc. In view of this bewildering flood of new information, the time was considered right to organize yet another update on H. pylori in the successful series 'Basic mechanisms to clinical cure' to define the 'state-of-affairs' in H. pylori research at this time. Our main objective was to integrate this new information in a series of top-quality presentations and discussions between investigators and clinicians, addressing all aspects of H. pylori research, and to review the current position and future research direc­ tions. The format included state-of-the-art presentations by world experts heavily involved in H. pylori research, followed by in-depth discussion on intriguing or controversial issues. The topics discussed were grouped according to the leading theme: characteristics of the organism, mode of transmission, mechanisms of H. pylori-induced inflammation, causation of disturbances of gastric secretory and motor function, aspects of clinical presentation and management, problems related to H. pylori-associated gastric adenocarcinoma and MALT-lymphoma, novel aspects of antimicrobial therapy, and vaccination. The meeting concluded with a synoptic agenda of suggested future studies for the microbiologist, the histopathologist and the clinician.

• antimicrobial
• antimicrobial therapy
• cancer
• carcinoma
• gastric cancer
• helicobacter pylori
• infection
• lymphoma
• vaccination
• infectious diseases

• Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Canada

  Richard H. Hunt

• Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands

  Guido N. J. Tytgat

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