Nuclear Factor кB

1. Front Matter

   Pages i-xi

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2. Activators and Target Genes of Rel/NF-кB Transcription Factors

   • T. Loop, H. L. Pahl

   Pages 1-48

3. NF-κB Activation by Tumor Necrosis Factor and Interleukin-1

   • I. Carpentier, S. Janssens, K. Heyninck, R. Beyaert

   Pages 49-67

4. NF-κB Activation by Card Proteins

   • J.-L. Poyet, E. S. Alnemri

   Pages 69-88

5. Viruses as Intruders in the Rel/NF-κB Signaling Pathway

   • T. D. Gilmore, G. Mosialos

   Pages 89-113

6. The IкB Kinase (IKK) Complex

   • U. Senftleben, M. Karin

   Pages 115-135

7. The Role of Ubiquitin In NF-кB Signaling

   • L. Deng, Z. J. Chen

   Pages 137-158

8. New Insights into the Regulation of Nf-кB

   • A. O’Mahony, L. F. Chen, W. C. Greene

   Pages 159-176

9. The Structural Biology of NF-κB

   • T. Huxford, G. Ghosh

   Pages 177-198

10. Tools to Interfere with NF-κB Activation

    • Y. Yamamoto, U. N. Verma, R. B. Gaynor

    Pages 199-219

11. Regulation of NF-кB by Glucocorticoids

    • K. De Bosscher, W. Vanden Berghe, G. Haegeman

    Pages 221-239

12. Genetic Analysis of NF-κB-Dependent Signaling Pathways in Mammalian Cells

    • X. Li, G. R. Stark

    Pages 241-264

13. Delineation of NF-кB Signaling by Gene Targeting

    • N. Suzuki, M. Bonnard, S. Suzuki, W.-C Yeh

    Pages 265-294

14. The Role of NF-κB in Inflammatory Diseases

    • E. Andreakos, I. Udalova, S. Sacre, B. M. Foxwell

    Pages 295-323

15. NF-кB in Genetic Disorders

    • G. Courtois, A. Israël

    Pages 325-334

16. NF-кB in the Vascular System

    • R. De Martin

    Pages 335-351

17. NF-κB in T-Lymphocyte Biology

    • O. Dienz, S. Bacher, M. L. Schmitz

    Pages 353-371

18. NF-кB in the Nervous System

    • B. Kaltschmidt, C. Kaltschmidt

    Pages 373-392

19. NF-κB in Oncogenesis and As a Target for Cancer Therapy

    • A. S. Baldwin Jr.

    Pages 393-408

20. Control of Immunity by Rel Proteins in Drosophila

    • P. Georgel

    Pages 409-421

Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio­ logical responses that it controls, the striking evolutionary conservation of struc­ ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.

• Mammalia
• apoptosis
• biology
• biomedicine
• cell
• cell biology
• cellular differentiation
• diseases
• inflammation
• nervous system
• oncogene
• phosphorylation
• protein
• structural biology
• transcription

• Department for Molecular Biomedical Research, Unit for Molecular Signal Transduction in Inflammation, Ghent University and Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium

  Rudi Beyaert

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