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Nuclear Factor кB

Regulation and Role in Disease

  • Book
  • © 2003

Overview

Editors:
  1. Rudi Beyaert

    1. Department for Molecular Biomedical Research, Unit for Molecular Signal Transduction in Inflammation, Ghent University and Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Activators and Target Genes of Rel/NF-кB Transcription Factors

    • T. Loop, H. L. Pahl
    Pages 1-48

  3. NF-κB Activation by Tumor Necrosis Factor and Interleukin-1

    • I. Carpentier, S. Janssens, K. Heyninck, R. Beyaert
    Pages 49-67

  4. NF-κB Activation by Card Proteins

    • J.-L. Poyet, E. S. Alnemri
    Pages 69-88

  5. Viruses as Intruders in the Rel/NF-κB Signaling Pathway

    • T. D. Gilmore, G. Mosialos
    Pages 89-113

  6. The IкB Kinase (IKK) Complex

    • U. Senftleben, M. Karin
    Pages 115-135

  7. The Role of Ubiquitin In NF-кB Signaling

    • L. Deng, Z. J. Chen
    Pages 137-158

  8. New Insights into the Regulation of Nf-кB

    • A. O’Mahony, L. F. Chen, W. C. Greene
    Pages 159-176

  9. The Structural Biology of NF-κB

    • T. Huxford, G. Ghosh
    Pages 177-198

  10. Tools to Interfere with NF-κB Activation

    • Y. Yamamoto, U. N. Verma, R. B. Gaynor
    Pages 199-219

  11. Regulation of NF-кB by Glucocorticoids

    • K. De Bosscher, W. Vanden Berghe, G. Haegeman
    Pages 221-239

  12. Genetic Analysis of NF-κB-Dependent Signaling Pathways in Mammalian Cells

    • X. Li, G. R. Stark
    Pages 241-264

  13. Delineation of NF-кB Signaling by Gene Targeting

    • N. Suzuki, M. Bonnard, S. Suzuki, W.-C Yeh
    Pages 265-294

  14. The Role of NF-κB in Inflammatory Diseases

    • E. Andreakos, I. Udalova, S. Sacre, B. M. Foxwell
    Pages 295-323

  15. NF-кB in Genetic Disorders

    • G. Courtois, A. Israël
    Pages 325-334

  16. NF-кB in the Vascular System

    • R. De Martin
    Pages 335-351

  17. NF-κB in T-Lymphocyte Biology

    • O. Dienz, S. Bacher, M. L. Schmitz
    Pages 353-371

  18. NF-кB in the Nervous System

    • B. Kaltschmidt, C. Kaltschmidt
    Pages 373-392

  19. NF-κB in Oncogenesis and As a Target for Cancer Therapy

    • A. S. Baldwin Jr.
    Pages 393-408

  20. Control of Immunity by Rel Proteins in Drosophila

    • P. Georgel
    Pages 409-421
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Keywords

About this book

Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio­ logical responses that it controls, the striking evolutionary conservation of struc­ ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.

Editors and Affiliations

  • Department for Molecular Biomedical Research, Unit for Molecular Signal Transduction in Inflammation, Ghent University and Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium

    Rudi Beyaert

Bibliographic Information

  • Book Title: Nuclear Factor кB

  • Book Subtitle: Regulation and Role in Disease

  • Editors: Rudi Beyaert

  • DOI: https://doi.org/10.1007/978-94-010-0163-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 2003

  • Hardcover ISBN: 978-1-4020-1434-5Published: 31 October 2003

  • Softcover ISBN: 978-94-010-3983-3Published: 23 November 2012

  • eBook ISBN: 978-94-010-0163-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 426

  • Topics: Immunology, Animal Anatomy / Morphology / Histology, Animal Biochemistry, Pharmacy, Cancer Research

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