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The Cornea in Normal Condition and in Groenouw’s Macular Dystrophy

  • Book
  • © 1980

Overview

Authors:
  1. Jules François

    1. Ophthalmological Clinic of the University of Ghent, Belgium

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    You can also search for this author in PubMed   Google Scholar

  2. Virgilio Victoria-Troncoso
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Table of contents (19 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Introduction

    1. Introduction

      • Jules François, Virgilio Victoria-Troncoso
      Pages 2-3

  3. Normal Keratocytes

    1. Front Matter

      Pages 5-5
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    2. Material and Methods

      • Jules François, Virgilio Victoria-Troncoso
      Pages 7-36

    3. Normal Keratocytes ‘In Situ’

      • Jules François, Virgilio Victoria-Troncoso
      Pages 37-44

    4. Architectonic of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 45-60

    5. The Keratocytes in the Process of Cicatrisation of the Corneal Stroma

      • Jules François, Virgilio Victoria-Troncoso
      Pages 61-77

    6. Keratocytes in Tissue Culture

      • Jules François, Virgilio Victoria-Troncoso
      Pages 79-92

  4. Pathologic Keratocytes (Macular Dystrophy of the Cornea)

    1. Front Matter

      Pages 93-93
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    2. I. Definition of Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 95-96

    3. Microscopical and Histochemical Study of Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 99-112

    4. Transmission Electron Microscopy of the Corneal Stroma in Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 113-121

    5. Scanning Electron Microscopy of the Corneal Stroma in Macular Dystrophy

      • Jules François, Virgilio Victoria-Troncoso
      Pages 123-125

    6. Changes of the Epithelium, the Base Membrane, the Endothelium and the Descemet’s Membrane in Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 127-138

    7. Histochemical and Microscopical Study of Corneal Cultures from Macular Dystrophy

      • Jules François, Virgilio Victoria-Troncoso
      Pages 139-150

    8. Transmission Electron Microscopy of Cultures of the Corneal Stroma in Macular Dystrophy

      • Jules François, Virgilio Victoria-Troncoso
      Pages 151-155

    9. Scanning Electron Microscopy of the Cultures of Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 157-159

    10. Vital Staining of the Lysosomes in Normal Keratocytes and in Keratocytes from Macular Dystrophy

      • Jules François, Virgilio Victoria-Troncoso
      Pages 161-171

    11. Active Biological Substance Present in Normal Keratocytes and Capable of Acting on the Stored Mucopolysaccharides in Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 173-175

    12. Pathogenesis of Macular Dystrophy of the Cornea

      • Jules François, Virgilio Victoria-Troncoso
      Pages 177-181
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Keywords

About this book

The three most striking characteristics of the cornea are: a) Its structure or rather its perfectly regular architectonic, by virtue of which it is transparent. b) The absence of vessels, the cornea being nourished by the perilimbic vessels, the endothelial surface in communication with the aqueous humour and the epithelial surface in contact with the pre-corneal film. c) The very slow turnover of the cells, that is to say the keratocytes, with the result that the metabolism of the cornea is very weak. It is this third characteristic which justifies our present investigation. The keratocytes, which are apparently inactive, have in fact a latent activity. They can be activated by central corneal incisions and also by tissue cultures. Under either of those conditions, the keratocytes become very active, develop all the cytoplasmic organites and produce mucopoly­ saccharides as well as the precursors of the collagen (Fig. 1). In order to study the pathological keratocyte, we chose a storage disease, wherein the catabolism of the mucopolysaccharides is blocked, namely the macular dystrophy of the cornea. We undertook the same investigation both for normal and for pathologi­ cal corneas and studied the keratocyte 'in situ' and in tissue cultures using various microscopical and histochemical techniques. In macular dystrophy, we investigated also the deteriorations secondary to the changes in the keratocytes.

Authors and Affiliations

  • Ophthalmological Clinic of the University of Ghent, Belgium

    Jules François

Bibliographic Information

  • Book Title: The Cornea in Normal Condition and in Groenouw’s Macular Dystrophy

  • Authors: Jules François, Virgilio Victoria-Troncoso

  • DOI: https://doi.org/10.1007/978-94-009-9177-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Dr. W. Junk bv Publishers 1980

  • Hardcover ISBN: 978-90-6193-161-4Due: 29 February 1980

  • Softcover ISBN: 978-94-009-9179-8Published: 10 November 2011

  • eBook ISBN: 978-94-009-9177-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 210

  • Topics: Ophthalmology

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