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Synthetic Substrates in Clinical Blood Coagulation Assays

  • Book
  • © 1980

Overview

Editors:
  1. H. R. Lijnen

    1. Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium

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  2. D. Collen

    1. Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium

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  3. M. Verstraete

    1. Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium

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Part of the book series: Developments in Hematology and Immunology (DIHI, volume 1)

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-IX
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Advantages, Pitfalls, and Snags with Chromogenic Substrates

      • H. C. Hemker
      Pages 3-9

  3. The Coagulation System

    1. Front Matter

      Pages 11-11
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    2. The Potential Use of Chromogenic Assays in the Routine Monitoring of Oral Anticoagulant Therapy

      • R. M. Bertina, E. A. Loeliger
      Pages 13-25

    3. Automated Control of Coumarin Therapy by Chromogenic Factor X Assay

      • M. F. Scully, R. S. Mibashan, A. D. J. Birch, J. K. Thumpston, I. R. McGregor, W. R. S. North et al.
      Pages 27-36

    4. Spectrophotometry Determination of Factor X with S-2222 in Anticoagulated and Cirrhotic Patients

      • G. Baele
      Pages 37-43

    5. An Automated Chromogenic Antithrombin III Method : Clinical Experience

      • J. W. Ten Cate
      Pages 45-50

    6. Antithrombin III and Factor Xa Determination in Patients with Low Dose Heparin and Hip Surgery

      • T. H. Schöndorf, H. G. Lasch
      Pages 51-62

    7. Heparin Concentration (S-2222) and Effect of Heparin Treatment (Bleeding Complications, Pulmonary Embolism and Clearing of the Thrombus)

      • H. A. Holm, U. Abildgaard, F. Laerum, T. Wolland
      Pages 63-69

  5. General Discussion and Conclusions

    1. Front Matter

      Pages 133-133
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    2. General Discussion and Conclusions

      • H. R. Lijnen, D. Collen, M. Verstraete
      Pages 135-141
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Keywords

About this book

This book contains the proceedings of a symposium on the use of synthetic substrates in clinical blood coagulation assays, which was held at the University of Leuven, Belgium, on March 1st, 1980. This meeting was organized in order to exchange and discuss recent develop­ ments and applications in this field. Advantages and disadvantages of synthetic substrates are discussed, while expert workers report on their practical experience with the use of chromogenic substrates in routine assays for blood coagulation and fibrinolysis. The indications when to perform antithrombin III, a2-antiplasmin, factor X and factor II determinations are discussed. For each of the determinations a critical evaluation of the chromogenic assay as compared to the classical assay is presented. The clinical relevance of these assays for anticoagulated and cirrhotic patients, detection of vitamin K deficiency, monitoring heparin therapy and the fibrinolytic system are discussed. Recent developments in the use of fluorogenic substrates for the assay of low concentrations of fibrin­ olytic activators are presented. Taking into account all practical, medical and economical con­ siderations an answer is prepared to the question "Are synthetic sub­ strates to be recommended for routine use?". To make this symposium useful, rapid publication of the proceedings has been undertaken. We are grateful to the participants in this meeting for their co­ operation and for their willingness to provide manuscripts of their presentations. The manuscripts provided by C. Kluft and H.H.D.M.

Editors and Affiliations

  • Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Leuven, Belgium

    H. R. Lijnen, D. Collen, M. Verstraete

Bibliographic Information

  • Book Title: Synthetic Substrates in Clinical Blood Coagulation Assays

  • Editors: H. R. Lijnen, D. Collen, M. Verstraete

  • Series Title: Developments in Hematology and Immunology

  • DOI: https://doi.org/10.1007/978-94-009-8910-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers bv, The Hague 1980

  • Hardcover ISBN: 978-90-247-2409-3Published: 30 September 1980

  • Softcover ISBN: 978-94-009-8912-2Published: 08 December 2011

  • eBook ISBN: 978-94-009-8910-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: IX, 141

  • Topics: Hematology

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