Recent Advances in Crohn’s Disease

1. Front Matter

   Pages i-xviii

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2. Definition and Assessment of Activity

   1. Front Matter

      Pages 1-1

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   2. Definition of Crohn’s Disease

      • F. T. De Dombal

      Pages 3-6

   3. The Crohn’s Disease Activity Index as a Clinical Instrument

      • W. R. Best, J. M. Becktel

      Pages 7-12

   4. Activity and Its Assessment in Crohn’s Disease

      • J. F. Fielding

      Pages 13-16

   5. An Index of Inflammatory Activity in Patients with Crohn’s Disease

      • P. A. M. Van Hees, Ph. Van Elteren, H. J. J. Van Lier, J. H. M. Van Tongeren

      Pages 17-21

   6. Summary of discussions relating to topics A1 to A4

      • A. S. Peña, Irene T. Weterman, C. C. Booth, W. Strober

      Pages 22-24

   7. A Clinical Scoring System for Chronic Inflammatory Bowel Disease in Children

      • J. D. Lloyd-Still, H. U. Wessel

      Pages 25-29

   8. Crohn’s Disease in Children: Diagnostic Problems and Procedures

      • A. C. Douwes, J. Fernandes, M. Van Caillie

      Pages 30-33

   9. Design, Early Results and Outlook of a Prospective Paediatric Crohn’s Disease Study

      • D. H. Shmerling

      Pages 34-37

   10. Summary of Discussions relating to topics A6 to A8

       • A. S. Peña, Irene T. Weterman, C. C. Booth, W. Strober

       Pages 38-38

   11. General Discussion and Conclusions

       • S. C. Truelove

       Pages 39-39

3. Morphological Aspects

   1. Front Matter

      Pages 41-42

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   2. Significance of Lip Biopsies in the Diagnosis of Crohn’s Disease [Routine Histology and Immunofluorescence]

      • M. K. Basu, I. M. Chesner, R. A. Thompson, P. Asquith

      Pages 43-46

   3. Duodenal Biopsy Cell Counts and Histopathology in Crohn’s Disease

      • S. C. Sommers, B. I. Korelitz

      Pages 47-51

   4. Does there Exist Any Correlation Between Clinical Findings and the Histopathology of Rectal Biopsy in Crohn’s Disease? A Morphometrical Study

      • P. Schmitz-Moormann, U. Werkmeister, G. W. Himmelmann, J. W. Brandes, H. Ehms

      Pages 52-58

   5. Summary of Discussions relating to topics B1 to B3

      • A. S. Peña, Irene T. Weterman, C. C. Booth, W. Strober

      Pages 59-61

   6. Focal Non-Specific Inflammation [FNI] in Crohn’s Disease

      • J. H. Yardley, S. R. Hamilton

      Pages 62-66

   7. Summary of Discussions relating to topic B5

      • A. S. Peña, Irene T. Weterman, C. C. Booth, W. Strober

      Pages 67-69

   8. The Histopathological Evolution of Crohn’s Disease

      • T. J. Chambers, B. C. Morson

      Pages 70-75

The study of disease entities as complex as Crohn's dis­ ease will increasingly require comprehensive knowledge of formerly unrelated areas of the medical sciences. To promote this broad approach, a conference was organized in which geneticists, morphologists, immunologists, and virologists participated as well as clinicians whose work is focused on Crohn's disease. Ample time was given to the presentation of major new findings in each of these areas, and comments were given by the participants in the various sections. This approach yielded many new ideas, because indiv iduals with very different backgrounds were able to address old problems from fresh angles. This volume, published in January, 1981, contains the papers presented dur ing the wor kshop held in June, 1980, in Noordwijk/Leiden, The Netherlands. In addition, we have in­ cluded the extensive discussions, edited by experts in the field, which followed each presentation. Finally, each main category is followed by a summary of the topic covered as well as many valuable conclusions concerning the significance of recent work and ideas for new directions in research. In the Preface, J.B. Kirsner gives a comprehensive review of the material, and in an Afterword A.J.Ch. Haex deals with a num­ ber of other aspects. We believe that this volume will be of value to a wide spectrum of scientists and clinicians and that it will help to establ ish the mul tid isciplinary approach to Crohn' s dis­ ease as the one that should predominate in the future.

• assessment
• cytogenetics
• epidemiology
• genetics
• immunology
• treatment

• Department of Gastroenterology, State University of Leiden, Leiden, The Netherlands

  A. S. Peña, Irene T. Weterman

• Clinical Research Centre, Harrow, UK

  C. C. Booth

• National Institutes of Health, National Cancer Institute, Bethesda, USA

  W. Strober

Policies and ethics