The Biological Effects of Glutamic Acid and Its Derivatives

1. Front Matter

   Pages i-4

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2. Hippocampal glutamate receptors

   • Michel Baudry, Gary Lynch

   Pages 5-18

3. Enzymatic synthesis and function of folylpolyglutamates

   • John J. McGuire, Joseph R. Bertino

   Pages 19-48

4. δ-Aminolaevulinic acid and amino acid neurotransmitters

   • M. J. W. Brennan, R. C. Cantrill

   Pages 49-58

5. γ-Glutamylamine cyclotransferase

   • Mary Lynn Fink, J. E. Folk

   Pages 59-67

6. GABA and the enteric nervous system

   • K. R. Jessen

   Pages 69-76

7. Post-translational carboxylation of preprothrombin

   • B. Connor Johnson

   Pages 77-121

8. Glutamate and aspartate agonists structurally related to ibotenic acid

   • Tage Honoré, Povl Krogsgaard-Larsen, Jan J. Hansen, Jørn Lauridsen

   Pages 123-128

9. GABA agonists

   • Povl Krogsgaard-Larsen, Erik Falch

   Pages 129-146

10. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture

    • Robert L. Macdonald, Anne B. Young

    Pages 147-162

11. Molecular characteristics of glutamate receptors in the mammalian brain

    • E. K. Michaelis, M. L. Michaelis, H. H. Chang, R. D. Grubbs, D. R. Kuonen

    Pages 163-179

12. Pyroglutamic acid

    • George N. Abraham, David N. Podell

    Pages 181-190

13. Gamma-carboxyglutamic acid

    • John P. Burnier, Marianne Borowski, Barbara C. Furie, Bruce Furie

    Pages 191-207

14. Folylpoly-γ-glutamate synthesis by bacteria and mammalian cells

    • David J. Cichowicz, Siang K. Foo, Barry Shane

    Pages 209-228

15. Immunocytochemical and autoradiographic localization of GABA system in the vertebrate retina

    • Jang-Yen Wu, Christopher Brandon, Y. Y. Thomas Su, Dominic M. K. Lam

    Pages 229-238

16. L-glutamate transport in renal plasma membrane vesicles

    • Bertram Sacktor

    Pages 239-251

17. Glutamate as a precursor of GABA in rat brain and peripheral tissues

    • Helen L. White

    Pages 253-259

18. The GABA postsynaptic membrane receptor-ionophore complex

    • Richard W. Olsen

    Pages 261-279

19. The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids

    • Vivian I. Teichberg, Ora Goldberg, Alberto Luini

    Pages 281-295

20. Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid

    • Theodore A. Hare

    Pages 297-304

the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA­ GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val­ rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres­ already had a significant impact on our under­ sion of seizures and the correlation between anti­ standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.

• Amino acid
• Aspartat
• Glutamat
• biochemistry
• translation

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