Advances in Research on Cholera and Related Diarrheas

1. Front Matter

   Pages i-viii

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2. Immunology and Vaccine Development

   1. Front Matter

      Pages 1-1

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   2. Role of Colonization Factor Antigen in Immunoprotection Against Enterotoxigenic Escherichia Coli Diarrhea

      • Dolores G. Evans, Francisco F. J. de la Cabada, Doyle J. Evans Jr.

      Pages 3-5

   3. The Ileal Loop test on Mice which were Orally Immunized with IF30

      • T. Ishihara, A. Ghoda

      Pages 7-11

   4. Local IgA Anamnestic Response Following Peroral Immunization with Shigella Flexneri Antigens

      • David F. Keren

      Pages 13-18

   5. Effects of the Oral Immunization with Live V. Cholerae on the Antibody Formation

      • Y. Komagata, A. Ghoda

      Pages 19-27

   6. Protection of Neonatal Piglets against Colibacillosis by Immunization of Dams with Procholeragenoid

      • E. Fürer, S. J. Cryz Jr., F. Dorner, R. Germanier

      Pages 29-33

   7. Efficacious Carriers for Multi-Specific Priming of a Mucosal IgA Response

      • Juliet A. Fuhrman, John J. Cebra

      Pages 35-40

   8. Oral Immunization for Cholera: Mucosal Antitoxic Immunity is Important and can Probably be Safely Achieved

      • Nathaniel F. Pierce, William C. Cray Jr., John B. Sacci Jr.

      Pages 41-48

   9. Texas Star-SR: Attenuated Vibrio Cholerae Oral Vaccine Candidate

      • Myron M. Levine, Robert E. Black, Mary Lou Clements, Charles R. Young, Takeshi Honda, Richard Finkelstein

      Pages 49-55

3. Bacteriology and Virulence Factors

   1. Front Matter

      Pages 57-57

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   2. Sugar Composition of Lipopolysaccharides of Family Vibrionaceae—Absence of 2-Keto-3-Deoxyoctonate (KDO) with the Exception of Vibrio Parahaemolyticus 06 and Plesiomonas Shigelloides—

      • Kazuhito Hisatsune, Seiichi Kondo, Takehiro Iguchi, Masaaki Machida, Shinobu Asou, Makoto Inaguma et al.

      Pages 59-74

   3. Enteropathogenicity and some Biological Features of Group F (Ef—6) Vibrio Isolates

      • Yasuo Kudoh, Masaaki Tsuno, Shigeru Matsushita, Sumio Yamada, Kenji Ohta, Senzo Sakai et al.

      Pages 75-86

   4. In Vitro and In Vivo Biologic Activities of Vibrio Fluvialis and its Toxic Products

      • D. E. Lockwood, S. H. Richardson, A. S. Kreger, M. Aiken, B. McCreedy

      Pages 87-99

   5. Influence of Salinity, Nutrient Concentration and Temperature on Growth and Survival of Vibrio Choleras in the Aquatic Environment

      • F. L. Singleton, R. W. Attwell, M. S. Jangi, R. R. Colwell

      Pages 101-112

   6. Lysogenicity of Vibrio Cholerae

      • Makoto Ohashi, Takeshi Terayama, Hiroshi Ushioda, Yasuo Kudoh, Masaaki Tsuno, Shigeru Matsushita et al.

      Pages 113-120

   7. Hemagglutinins (Colonization Factors?) Produced by Vibrio Cholerae

      • Richard A. Finkelstein, Larry F. Hanne

      Pages 121-125

   8. Experimental Cholera in Germ-free and Gnotobiotic Piglets

      • Eiji Tokunaga, Toyoharu Muraoka, Shunsuke Akiyama, Kazusuke Kudo, Nobuya Ohtomo

      Pages 127-134

   9. Isolation of Hybridoma Cell Lines Producing Antibody against Cholera Enterotoxin

      • M. Robb, J. C. Nichols, J. R. Murphy

      Pages 135-143

4. Clinical Studies

   1. Front Matter

      Pages 145-145

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The United States-Japan Cooperative Medical Science Program was initiated in 1965 by joint agreement between the President of the United States and the Prime Minister of Japan. The purpose of the Program was to promote cooperative biomedical research between the two countries, especially on health problems of recognized impor­ tance in Asia. Cholera was designated as one topic of mutual interest. Panels of scientists from each country were formed, and these met to select priority areas for research. The Cholera Panels initially defined two major goals: 1) improved and simplified therapy for cholera, and 2) better methods for immunization. Progress in the pursuit of these goals led to the recognition that bacteria other than Vibrio cholerae are also important causes of acute dehydrating diarrhea which resembles cholera in its manifestations and patho­ genesis; most notable among these are enterotoxinogenic strains of Escherichia coli. Accordingly, panel guidelines were expanded to include all diarrheal diseases that involve fluid loss caused by an enterotoxin. More recently, studies have shown that vibrios, including V. cholerae, have a distinct environmental life cycle that is probably an impor­ tant factor in the epidemiology of vibrio infections. For this reason, the panel guidelines were again expanded to include studies on the environmental ecology of vibrios. A major project of the Joint Cholera Panels has been the organization and spon­ sorship of an annual conference on cholera and related diarrheal diseases.

• antibody
• antigen
• bacteriology
• cell
• gene
• genetics
• immunology
• infection
• toxin
• vaccine

• Department of Microbiology, Toho University, Tokyo, Japan

  S. Kuwahara

• Baltimore Hospitals and Johns Hopkins University School of Medicine, Baltimore, USA

  N. F. Pierce

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