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Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions

  • Book
  • © 1984

Overview

Editors:
  1. Théophile Godfraind

    1. Laboratoire de Pharmacodynamie Générale et de Pharmacologie, Université Catholique de Louvain, Brussels, Belgium

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  2. Arnold G. Herman

    1. Department of Medicine, University of Antwerp, Wilrijk, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  3. Donald Wellens

    1. Janssen Pharmaceutica, Beerse, Belgium

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 40)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-vii
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  3. Calcium entry blockers and peripheral circulatory function

    1. Front Matter

      Pages 43-43
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    2. Calcium-ions and excitation contraction coupling in vascular smooth muscle cells

      • R. Casteels
      Pages 45-52

    3. Laser microprobe mass analysis (LAMMA) as a technique to quantitate Ca2+ ions

      • S. De Nollin, W. Jacob, R. Hertsens
      Pages 53-58

    4. Vascular pharmacology of calcium entry blockers

      • J. M. Van Nueten
      Pages 59-72

    5. Calcium homeostasis in human red blood cells

      • H.J. Schatzmann
      Pages 73-79

    6. Impact of Ca2+ entry blockers on Ca2+-dependent mechanisms in red blood cells, platelets and endothelial cells

      • F. De Clerck, J. Hladovec
      Pages 81-90

    7. Red blood cell microrheology and calcium antagonists

      • J. F. Stoltz
      Pages 91-102

    8. Calcium entry blockers in the treatment of peripheral obliterative arterial disease

      • T. Di Perri, F. Laghi Pasini, M. Guerrini
      Pages 103-110

  4. Calcium entry blockers and myocardial function

    1. Front Matter

      Pages 111-111
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    2. Pharmacology of calcium entry blockers in animal and human coronary arteries

      • T. Godfraind, R. C. Miller
      Pages 113-124

    3. Calcium paradox and calcium entry blockers

      • T. J. C. Ruigrok, M. A. Slade, W. G. Nayler, F. L. Meijler
      Pages 125-134

    4. Myocardial oxygen deprivation and calcium deprivation: ultrastructural characteristics and clinical significance

      • G. R. Bullock, D. J. Hearse
      Pages 135-143

    5. Basic and clinical aspects of myocardial protection by calcium entry blockers

      • M. Borgers, W. Flameng
      Pages 145-153

    6. Effect of calcium entry blockers on impaired left ventricular wall motion

      • P. F. Cohn
      Pages 155-160
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Keywords

About this book

2 The free internal Ca+ concentration in human red cells is set according to the leak­ 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca­ 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady­ 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con­ 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec­ 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra­ tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).

Editors and Affiliations

  • Laboratoire de Pharmacodynamie Générale et de Pharmacologie, Université Catholique de Louvain, Brussels, Belgium

    Théophile Godfraind

  • Department of Medicine, University of Antwerp, Wilrijk, Belgium

    Arnold G. Herman

  • Janssen Pharmaceutica, Beerse, Belgium

    Donald Wellens

Bibliographic Information

  • Book Title: Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions

  • Editors: Théophile Godfraind, Arnold G. Herman, Donald Wellens

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-009-6033-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, The Hague 1984

  • Hardcover ISBN: 978-0-89838-658-5Due: 31 May 1984

  • Softcover ISBN: 978-94-009-6035-0Published: 04 November 2011

  • eBook ISBN: 978-94-009-6033-6Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: 325

  • Topics: Cardiology

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