Receptor Regulation

1. Front Matter

   Pages i-viii

   PDF

2. Introduction

   • Robert J. Lefkowitz

   Pages 1-5

3. The Insulin Receptor and its Function

   • Emmanuel van Obberghen, Jesse Roth

   Pages 7-40

4. EGF: Receptor Interactions and the Stimulation of Cell Growth

   • Graham Carpenter, Stanley Cohen

   Pages 41-66

5. Regulation of Prolactin Receptors in Target Cells

   • Robert P. C. Shiu, Henry G. Friesen

   Pages 67-81

6. Regulation of Adrenergic Receptors

   • Albert O. Davies, Robert J. Lefkowitz

   Pages 83-121

7. Denervation: Cholinergic Receptors of Skeletal Muscle

   • Douglas M. Fambrough

   Pages 123-142

8. Insulin Receptors in Disorders of Glucose Tolerance and Insulin Sensitivity

   • Emmanuel van Obberghen, Flora de Pablo, Jesse Roth

   Pages 143-160

9. Myasthenia Gravis and the Nicotinic Cholinergic Receptor

   • Jon Lindstrom, Andrew Engel

   Pages 161-214

10. Thyrotropin Receptor Antibodies

    • Bernard Rees Smith

    Pages 215-244

11. Back Matter

    Pages 245-253

    PDF

ROBERT J. LEFKOWITZ, M. D. Receptor Regulation (Receptors and Recognition, Series B, Volume 13) Edited by R. J. Lefkowitz Published in 1981 by Chapman and Hall, 11 New Fetter Lane, London EC4P 4EE © 1981 Chapman and Hall The study of hormone and drug receptors has become one of the most excit­ ing and rapidly moving areas of biomedical research. Elucidation of receptor mechanisms and receptor structure has become the common goal of many scientists from diverse backgrounds. The rapid advances achieved have been due, in large part, to the concentrated effort of workers from a variety of disciplines including classical pharmacology, biochemistry, endocrinology, cell biology, genetics' and molecular biology, among others. Hormone and drug receptors appear to be of three major types, which may be classified by their cellular locations. Found in the plasma membranes of cells are the receptors for a wide variety of polypeptide hormones, catecholamines and a variety of neurotransmitters. Included within this group are those receptors coupled to the enzyme adenylate cyclase. The second group of receptors are the soluble cytoplasmic receptors for the steroid hormones. A third type of hormone receptor is the receptor for the thyroid hormones which appears to be confined to the nucleus. Not only may these different types of receptor be distinguished in terms of their cellular locations but also by their mechanisms of action.

• biology
• cell
• cell biology
• cells
• chemistry
• cytoplasm
• endocrinology
• growth
• membrane
• molecular biology
• plasma membrane
• polypeptide
• receptor
• receptors
• regulation

• Duke University Medical Center, Durham, USA

  R. J. Lefkowitz

Policies and ethics