Prostaglandins and Fertility Regulation

1. Front Matter

   Pages i-ix

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2. Physio-pharmacological Parameters

   1. Front Matter

      Pages 1-1

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   2. Potential for prostaglandin use in controlling human reproduction

      • K. T. Kirton, F. A. Kimball

      Pages 3-10

   3. Metabolism and pharmacokinetics of prostaglandin analogs in man

      • K. Gréen

      Pages 11-19

   4. Prostaglandins in the regulation of non-pregnant uterine contractility

      • V. Lundström

      Pages 21-25

   5. Effects of prostaglandins on the human non-pregnant uterus and ovary

      • M. K. Toppozada

      Pages 27-57

   6. Prostaglandin-induced changes in the pregnant human cervix

      • W. Rath, P. Theobald, H. Kühnle, W. Kuhn

      Pages 59-73

   7. Interaction between prostaglandins and catecholamines on cervical collagen

      • L. Wilhelmsson, A. Norström, J. Tjugum, L. Hamberger

      Pages 75-80

3. Clinical Applications

   1. Front Matter

      Pages 81-81

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   2. Self-administration at home of prostaglandin for termination of early pregnancy

      • M. Bygdeman, N. J. Christensen, K. Gréen, O. Vesterqvist

      Pages 83-90

   3. Menstrual induction and cervical priming prior to evacuation

      • N. H. Lauersen, Z. R. Graves

      Pages 91-105

   4. Intra-amniotic Prostaglandins for mid-trimester abortion

      • J. J. Amy

      Pages 107-118

   5. Intramuscular administration of 15-methyl prostaglandin F2α and laminaria insertion for termination of mid-trimester pregnancy

      • S. D. Sharma, V. M. Steinmiller, R. W. Hale

      Pages 119-128

   6. Side-effects of natural prostaglandins

      • T. H. Lippert

      Pages 129-139

   7. Epilogue

      • E. S. E. Hafez

      Pages 141-149

4. Back Matter

   Pages 151-157

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The role of prostaglandins in physiological events and pathological disorders related to human reproduction has been most actively investigated in the past decade. Their clinical use for fertility regulation, extensively evaluated, represents the most common clinical indication for the administration of these remarkable compounds. Thus, it is most appropriate to update the available information related to the use of prostaglandins in the regulation of human fertility to provide a background document for the benefit of clinicians and scientists. Invited experts of international reputation from various parts of the world have contributed, each in his own area of interest, to offer this book, which we hope will fill an existing gap. M. T. M. B. E. S. E. H. ix 1 Potential for prostaglandin use in controlling human reproduction K. T. KIRTON and F. A. KIMBALL BACKGROUND It was observed in 1930 that seminal plasma of a number of species contained very large amounts of substance(s) capable of altering uterine motility. These substances were subsequently demonstrated to be prostaglandins (PGs); this began the early and continued association of this group of compounds with reproduction. The activity was found to be associated with a fraction containing lipid-soluble acids, derived from prostanoic acid. Restrictions imposed by obscure sources and small amounts of material available for testing were initially impediments to their study.

• Uterus
• fertility
• pregnancy
• regulation
• reproduction

• Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Alexandria, Egypt

  M. K. Toppozada

• Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm 60, Sweden

  M. Bygdeman

• Department of Physiology, Reproductive Health Center, Medical University of South Carolina, Charleston, USA

  E. S. E. Hafez

Policies and ethics