Enzyme Chemistry

1. Front Matter

   Pages i-viii

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2. Infant enzyme chemistry

   • Colin J. Suckling

   Pages 1-7

3. The mechanistic basis of enzyme catalysis

   • Ronald Kluger

   Pages 8-39

4. Chemical models of coenzyme catalyses

   • Seiji Shinkai

   Pages 40-77

5. Selectivity in synthesis — chemicals or enzymes

   • Colin J. Suckling

   Pages 78-118

6. Enzymes as targets for drug design

   • Barrie Hesp, Alvin K. Willard

   Pages 119-161

7. Metal ions in biological systems

   • Donald H. Brown, W. Ewen Smith

   Pages 162-195

8. Enzyme-level studies of the biosynthesis of natural products

   • David E. Cane

   Pages 196-231

9. The impact of enzymology in biochemistry and beyond

   • Keith E. Suckling

   Pages 232-251

10. Back Matter

    Pages 252-255

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In the molecular sciences, enzyme chemistry occupies a special niche as one of the major contact points between chemical and biological disciplines. The special properties of enzymes as selective and efficient catalysts are so central to current challenges to chemists that the development of enzyme chemistry in the past thirty years has been a major stimulus to chemical research in general. On the one hand studies of the intrinsic properties of enzymes and, on the other hand, their applications to synthesis, drug design, and biosynthesis have had an immense impact. This book brings together in one volume essays describing several such fields with emphasis on the applications. It would be unnecessarily repetitious to outline the approach and contents of the book in a Preface; the first short chapter is more eloquent than a formal Preface can be. I shall therefore encourage you to begin with the Introduction in Chapter 1 and here I wish to extend my warm thanks to those who have contributed to the production of this book: the authors for their acceptance of the overall concept of the book and for the thoughtfulness of their writing; Dr Charles Suckling, FRS and Professor Hamish Wood for their constructive criticism of the whole book; and Dr John Buckingham and his colleagues at Chapman and Hall for their efficiency and enthusiasm in transforming the typescripts into the book that you now hold. Colin J. Suckling University of Strathclyde Contributors Donald H.

• Coenzym
• biochemistry
• enzyme
• enzymology
• natural product

• University of Strathclyde, UK

  Colin J. Suckling

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