Interrelationship Among Aging, Cancer and Differentiation

1. Front Matter

   Pages i-x

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2. Interrelationships Among Aging, Cancer and Differentiation

   • Edward L. Schneider

   Pages 1-5

3. Deceleration of Cancer Mortality Rates with Age and Time

   • Jacob A. Brody, Donald F. Everett Jr.

   Pages 7-13

4. Clinical Aspects of Cancer in the Elderly

   • Harvey Jay Cohen

   Pages 15-21

5. Overview of the Pathobiology of Aging

   • George M. Martin

   Pages 23-34

6. Regulators of Growth, Differentiation and the Reversal of Malignancy

   • Leo Sachs

   Pages 35-42

7. Transforming Genes of Human Malignancies

   • Alessandra Eva, Stuart A. Aaronson, Steven R. Tronick

   Pages 43-57

8. Cancer Cells as Probes of Embryonic Development

   • G. Barry Pierce, Robert S. Wells

   Pages 59-65

9. Alterations in Epidermal Differentiation in Skin Carcinogenesis

   • Stuart H. Yuspa

   Pages 67-81

10. Virus Transformation as a Function of Age, Differentiation and Hereditary Factors

    • W. H. Kirsten

    Pages 83-86

11. Negative Control of Viral and Cellular Enhancer Activity by the Products of the Immortalizing E1A Gene of Human Adenovirus-2

    • Emiliana Borrelli, René Hen, Pierre Chambon

    Pages 87-99

12. Expression of Two Murine Gene Families in Transformed Cells and Embryogenesis

    • Jeffrey A. Moshier, Richard A. Morgan, Ru Chih C. Huang

    Pages 101-116

13. Methotrexate Resistance, Gene Amplification, and Somatic Cell Heterogeneity

    • Robert T. Schimke

    Pages 117-120

14. Macromolecular Correlates of Cellular Senescence and Cancer

    • Robert J. Shmookler Reis, Arun Srivastava, Samuel Goldstein

    Pages 121-132

15. Dominance of In Vitro Senescence in Somatic Cell Hybridization and Biochemical Experiments

    • James R. Smith, Olivia M. Pereira-Smith

    Pages 133-141

16. Studies on Gene Structure and Function in Aging: Collagen Types I and II and the Albumin Genes

    • D. Gershon, K. Kohno, G. R. Martin, Y. Yamada

    Pages 143-148

17. Retrovirus-Like Gene Families in Normal Cells: Potential for Affecting Cellular Gene Expression

    • E. Keshet, A. Itin, G. Rotman

    Pages 149-161

18. The Conformational Effects of UV Induced Damage on DNA

    • David A. Pearlman, Stephen R. Holbrook, Sung-Hou Kim

    Pages 163-171

19. DNA Supercoiling and Gene Expression

    • James C. Wang

    Pages 173-181

20. Intermediates in Transcription Initiation and Propagation

    • David C. Straney, Donald M. Crothers

    Pages 183-186

In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl­ nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo­ gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.

• Monoclonal Antibodies
• antibody
• biology
• cellular differentiation
• embryo
• experiment
• genes
• genome
• hybridization
• infection
• molecular basis
• protein
• quantum chemistry
• structure
• transcription

• Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

  Bernard Pullman

• Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, USA

  Paul O. P. Ts’o

• National Institute on Aging, National Institutes of Health, Bethesda, USA

  Edmond L. Schneider

Policies and ethics