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Blood Filtration and Blood Cell Deformability

Summary of the proceedings of the third workshop held in London, 6 and 7 October 1983, under the auspices of the Royal Society of the Medicine and the Groupe de Travail sur la Filtration Erythrocitaire

  • Conference proceedings
  • © 1985

Overview

Editors:
  1. John Dormandy

    1. St. George’s Hospital, London, UK

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Part of the book series: Developments in Hematology and Immunology (DIHI, volume 12)

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Table of contents (31 papers)

  1. Front Matter

    Pages I-X
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  2. Introduction and welcome

    1. Introduction and welcome

      • J. A. Dormandy
      Pages 1-1

  3. Welcome on behalf of the Groupe de Travail sur la Filtration Erythrocytaire

    1. Welcome on behalf of the Groupe de Travail sur la Filtration Erythrocytaire

      • G. A. Marcel
      Pages 3-3

  4. The place of red cell filterability in the microcirculation

    1. The place of red cell filterability in the microcirculation

      • P. Gaehtgens
      Pages 5-9

  5. Effect of white blood cells on red cell filterability and the measurement of red cell deformability

    1. Front Matter

      Pages 11-11
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    2. Effect of white blood cells on red cell filterability

      • R. Skalak
      Pages 13-14

    3. Filterability of leucocyte suspensions

      • S. Chien
      Pages 15-16

    4. Effects of white blood cells in filtration measurements

      • M. Hanss
      Pages 17-17

    5. Qualitative and quantitative effects of white blood cells in a positive-pressure filtration system

      • G. D. O. Lowe
      Pages 18-19

    6. Effect of contaminating leucocytes on erythrocyte filterability

      • J. Stuart
      Pages 20-22

    7. Non-white cell clogging

      • J. Dormandy
      Pages 23-24

    8. Summary

      • H. J. Meiselman
      Pages 25-26

  6. Preparation of blood samples for filtration studies

    1. Front Matter

      Pages 27-27
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    2. Anticoagulant effects on the measurement of erythrocyte filterability

      • J. Stuart, I. Juhan-Vague
      Pages 29-33

    3. Effect of time delay from venepuncture on red cell rheology

      • A. J. Barnes
      Pages 34-35

    4. Red cell age distribution in blood centrifuged to remove leucocytes

      • M. Hanss
      Pages 36-36

    5. Erythrocyte volume stability in selected iso-osmotic buffers

      • H. J. Meiselman
      Pages 37-40

    6. Influence of the suspending medium on red blood cell filtration

      • S. Coccheri
      Pages 41-42

    7. Summary

      • J. Stuart
      Pages 43-44

    8. Comparison of different filtration techniques

      • G. A. Marcel
      Pages 45-51
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About this book

H. J. Meiselman From the theoretical studies of Dr. Skalak, it is clear that white cells can significantly influence the pressure-time profile of a red cell/white cell suspen­ sion, and that the presence of even a small amount of relatively rigid white cells can have a profound effect on the filtration pressure during the latter portion of a filtration experiment. Conversely, white cell effects, regardless of their relative rigidity, are shown to have only minimal effects during the very early (i. e. , 0-2 seconds) phases of the filtration process. Dr. Chien's experimental data support these theoretical studies, in that white cells of different mechan­ ical properties exhibit different pressure-time curves; pressure-time data for mixtures of leucocytes show shapes which can be predicted from the behavior of relatively homogeneous cell populations. The insensitivity of the very early portions of the filtration process to white cells is again reflected in the calculations made by Dr. Hanss. Using the nominal dilutions, white cell concentrations and the total volume of filtered cell suspension, he indicates that usually less than 1 pore out of 100 is liable to blockage by white cells. He thus concludes that, at the 1% accuracy level, initial filtration data should not be affected by mechanical pore blockage by white cells. Experimental studies by Dr. Lowe and Dr. Stuart question the WBC­ insensitivity of the early portion of the filtration process. Using a constant flow system, Dr.

Editors and Affiliations

  • St. George’s Hospital, London, UK

    John Dormandy

Bibliographic Information

  • Book Title: Blood Filtration and Blood Cell Deformability

  • Book Subtitle: Summary of the proceedings of the third workshop held in London, 6 and 7 October 1983, under the auspices of the Royal Society of the Medicine and the Groupe de Travail sur la Filtration Erythrocitaire

  • Editors: John Dormandy

  • Series Title: Developments in Hematology and Immunology

  • DOI: https://doi.org/10.1007/978-94-009-5008-5

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Dordrecht 1985

  • Softcover ISBN: 978-0-89838-714-8Published: 30 September 1985

  • eBook ISBN: 978-94-009-5008-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 110

  • Number of Illustrations: 3 b/w illustrations

  • Topics: Hematology

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