Immunotoxicology

1. Front Matter

   Pages I-XXVII

   PDF

2. Session I

   1. A Toxicologist’s View of Immunotoxicology

      • L. C. Zbinden

      Pages 1-11

   2. The Cells of the Immune System, an Update on Their Interactions and Signals

      • L. Adorini

      Pages 12-23

   3. Relationship Between the Immune System and Cancer

      • R. W. Baldwin

      Pages 24-34

   4. The Immune System and Infections

      • P. Lambert

      Pages 35-38

   5. Mechanisms of Autoimmunity

      • Helga Gleichmann, Ernst Gleichmann

      Pages 39-60

3. Session II

   1. Primary Immunodeficiencies

      • J. L. Touraine

      Pages 61-68

   2. The Neoplastic Consequences of Immunodepression

      • I. Penn

      Pages 69-82

   3. Immunological Abnormalities in the Acquired Immunodeficiency Syndrome

      • A. H. Rook, J. F. Manischewitz, A. S. Fauci

      Pages 83-97

   4. Monitoring the Human Immune System

      • G. Riethmueller, H. W. L. Ziegler-Heitbrock, E. P. Rieber

      Pages 98-103

   5. Immunorestoration in Secondary Immunodeficiency

      • J. W. Hadden

      Pages 104-124

4. Session III

   1. The Role of Histopathology in Assessment of Immunotoxicity

      • J. G. Vos

      Pages 125-134

   2. Experience with Validation of Methodology for Immunotoxicity Assessment in Rodents

      • Jack H. Dean, Lloyd D. Lauer, Robert V. House, Edward C. Ward, Michael J. Murray

      Pages 135-158

   3. An In Vitro Model for Studying Cellular and Molecular Mechanisms of Thymic Atrophy Induced by Chlorinated Aromatic Compounds

      • William F. Greenlee, Karen M. Dold, Rosemarie Osborn

      Pages 159-170

   4. The Gut Associated Lymphoid Tissue as a Model of a Specialized Immune Subsystem

      • J. G. Hall

      Pages 171-191

   5. Immunodepressive Drugs as Prototype Immunotoxicants

      • F. Spreafico, A. Merendino, L. Braceschi, S. Sozzani

      Pages 192-207

   6. The Toxicology of Biological Response Modifiers

      • E. Mihich, P. M. Kanter

      Pages 208-218

   7. MTP-PE, a Synthetic Lipophilic Muramyltripeptide: Biological and Toxcological Properties

      • D. G. Braun, P. Dukor, B. Lukas, G. Schumann, L. Tarcsay, M. Court et al.

      Pages 219-233

5. Session IV

   1. Altered Immune Function and Host Resistance Following Exposure to Common Airborne Pollutants

      • Donald E. Gardner, Judith A. Graham

      Pages 234-257

   2. Immunotoxicity of Organotin Compounds. A Cell Biological Approach to Dialkyltin Induced Thymus Atrophy

      • A. H. Penninks, W. Seinen

      Pages 258-278

IX The International Seminar on the Immunological System as a Target for Toxic Damage was held at The Commission of the European Communities (CEC) in Luxembourg on 6-9 November 1984. It was organized by the CEC and the International Programme on Chemical Safety of UNEP/ILO/WHO with the support of the u. S. Environmental Protection Agency and the National Institute of Environmental Health Sciences - USA and with the participation of the International Society of Immunophar­ macology. These bodies are actively concerned with the scientific and applied aspects of immunotoxicology. The Seminar consisted of thirty-four invited papers and three major panel discussions covering current and future test strategies for the screening of immunotoxic substances, hypersensitivity and the health implications of immunotoxico­ logical problems. It was attended by more than 200 scien­ tists from 27 countries representing all the Member states of the European Economic Community and the six Regions of the World Health Organization. These scientists represented many different disciplines and interests. The Seminar's principal objectives were: a review of recent advances in knowledge concerning the structure, function and dysfunction of the immunological system; - a review of the effects of xenobiotics on the immune system in animals and humans; an examination of the human health implications of immunotoxicity; discussion and critical analysis of the procedures for the assessment of immunological damage, a discussion of needs for the further development of laboratory and epidemiological methods and their validation, and a consideration of current test strategies.

• Thymus
• autoimmunity
• depression
• environment
• environmental chemicals
• immunodeficiency
• immunomodulation
• infection
• infections
• pathology
• pollutants
• research
• resistance
• toxicity
• toxicology

• Commission of the European Communities, Luxembourg

  A. Berlin

• Chemical Industry Institute of Toxicology, Research Triangle Park, USA

  J. Dean

• International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland

  M. H. Draper, E. M. B. Smith

• Institute of Pharmacological Research “Mario Negri”, Milan, Italy

  F. Spreafico

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