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Pathogenesis and Treatment of Diabetes Mellitus

  • Book
  • © 1986

Overview

Editors:
  1. J. K. Radder

    1. Department of Endocrinology and Metabolism, Leiden University Hospital, Leiden, The Netherlands

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  2. H. H. P. J. Lemkes

    1. Department of Endocrinology and Metabolism, Leiden University Hospital, Leiden, The Netherlands

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  3. H. M. J. Krans

    1. Department of Endocrinology and Metabolism, Leiden University Hospital, Leiden, The Netherlands

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XII
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  2. Pathogenesis of Diabetes Mellitus

    1. Type I Diabetes Mellitus

      1. Introduction: Type I Diabetes Mellitus
        • J. K. Radder
        Pages 1-10
      2. Autoimmune pathogenesis of viral diabetes
        • P. G. Babu, S. A. Huber, J. E. Graighead
        Pages 11-15
      3. Immunological features of insulin-dependent diabetes mellitus
        • F. Beeker, G. F. Bottazzo
        Pages 16-26
      4. Genetic counselling in Diabetes Mellitus
        • R. B. Tattersall
        Pages 27-32

    2. Type II Diabetes Mellitus

      1. Introduction: Pathogenesis of type II Diabetes Mellitus
        • H. M. J. Krans
        Pages 33-38
      2. Insulin secretion in noninsulin-dependent Diabetes Mellitus
        • V. Broadstone, W. K. Ward, J. G. Beard, J. D. Best, J. B. Halter, R. Judzewitsch et al.
        Pages 39-57
      3. Insulin antagonism
        • P. J. Lefebvre, A. S. Luyckx
        Pages 58-62
      4. The contribution of the central nervous system to the regulation of insulin release and the stabilization of blood glucose
        • A. B. Steffens, P. G. M. Luiten
        Pages 63-74
      5. Cellular insulin resistance
        • Tj. Wieringa
        Pages 75-82

  3. Treatment of Diabetes Mellitus

    1. Diet and hypoglycaemic agents

      1. Introduction: Diet and hypoglycaemic agents
        • J. L. Touber
        Pages 83-90
      2. Diet and Diabetes
        • R. G. Josse, A. L. Jenkins, D. J. A. Jenkins
        Pages 91-102
      3. Oral hypoglycaemic drugs
        • H. Keen, S. Ng Tang Fui
        Pages 103-120

    2. Insulin

      1. Introduction: Insulin treatment
        • J. Terpstra
        Pages 121-122
      2. Hyperinsulinaemia
        • E. R. Trimble
        Pages 123-130
      3. Insulin: The physiological basis of its administration
        • D. R. Matthews
        Pages 131-141
      4. Diabetes Technology: From the pump to the microprocessor
        • A. M. Albisser, B. S. Leibel
        Pages 142-151

    3. Pancreas transplantation

      1. Introduction: Pancreas transplantation
        • H. H. P. J. Lemkes
        Pages 152-155
      2. Current state of pancreas transplantation
        • P. McMaster, W. A. Jurewics, B. H. Gunson, R. M. Kirby
        Pages 156-165

  4. Back Matter

    Pages 167-172
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Keywords

About this book

In this book on diabetes mellitus both the pathogenesis and treat­ ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol­ ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre­ disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto­ immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out­ break of the disease, the destructive process has already been active for years.

Editors and Affiliations

  • Department of Endocrinology and Metabolism, Leiden University Hospital, Leiden, The Netherlands

    J. K. Radder, H. H. P. J. Lemkes, H. M. J. Krans

Bibliographic Information

  • Book Title: Pathogenesis and Treatment of Diabetes Mellitus

  • Editors: J. K. Radder, H. H. P. J. Lemkes, H. M. J. Krans

  • DOI: https://doi.org/10.1007/978-94-009-4301-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Dordrecht 1986

  • Softcover ISBN: 978-94-010-8411-6Published: 27 September 2011

  • eBook ISBN: 978-94-009-4301-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 188

  • Topics: Internal Medicine, Diabetes

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