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The Future of Predictive Safety Evaluation

In Two Volumes Volume 1

  • Book
  • © 1986

Overview

Editors:
  1. A. N. Worden

    1. Cantab Group, Cambridge, England

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  2. D. V. Parke

    1. Department of Biochemistry, University of Surrey, Guildford, England

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  3. J. Marks

    1. Girton College, Cambridge, England

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction

    1. Introduction

      • A. N. Worden, D. V. Parke, J. Marks
      Pages 1-12

  4. The Needs (Non-pharmaceutical)

    1. Front Matter

      Pages 99-99
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    2. Foods and Food Additives

      • D. M. Conning, K. R. Butterworth
      Pages 101-107

    3. Industrial Chemicals

      • M. A. Cooke
      Pages 109-116

    4. Evaluating the Hazards of Pesticides

      • G. J. Turnbull
      Pages 117-133

    5. Cosmetics, Toiletries and Household Products

      • N. Van Abbé
      Pages 135-151

    6. Substances of Abuse

      • J. Marks
      Pages 153-167

  5. Preclinical: In Vitro and Ex Vivo Approaches

    1. Front Matter

      Pages 169-169
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    2. Cellular and In Vitro Techniques

      • P. Knox
      Pages 171-180

    3. Immunological Aspects

      • K. Miller, S. Nicklin
      Pages 181-194

    4. Genetic Toxicology Testing

      • B. J. Dean
      Pages 195-209

    5. The Role of Dynamic Mathematical Models

      • E. R. Carson
      Pages 211-215
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Keywords

About this book

A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes­ tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con­ cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.

Editors and Affiliations

  • Cantab Group, Cambridge, England

    A. N. Worden

  • Department of Biochemistry, University of Surrey, Guildford, England

    D. V. Parke

  • Girton College, Cambridge, England

    J. Marks

Bibliographic Information

  • Book Title: The Future of Predictive Safety Evaluation

  • Book Subtitle: In Two Volumes Volume 1

  • Editors: A. N. Worden, D. V. Parke, J. Marks

  • DOI: https://doi.org/10.1007/978-94-009-4139-7

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: MTP Press Limited 1986

  • Softcover ISBN: 978-94-010-8336-2Published: 13 October 2011

  • eBook ISBN: 978-94-009-4139-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 224

  • Topics: Pharmacology/Toxicology

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