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Recognition of M. leprae antigens

  • Book
  • © 1987

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Authors:
  1. Tom Ottenhoff

    1. Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands
      Armauer Hansen Research Institute, Addis Abeba, Ethiopia

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  2. René Vries

    1. Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands

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Part of the book series: Developments in Hematology and Immunology (DIHI, volume 17)

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Table of contents (10 chapters)

  1. Front Matter

    Pages 1-6
    Download chapter PDF

  2. Introduction

    • Tom Ottenhoff, RenĂ© de Vries
    Pages 7-11

  3. MHC Class II Ir/Is Gene Controlled Antigen Specific T Cell Activation and Disease Susceptibility: Leprosy, a Human Model

    • Tom Ottenhoff, RenĂ© de Vries
    Pages 12-51

  4. HLA Class-II-Restricted Mycobacterium Leprae-Reactive T-Cell Clones from Leprosy Patients Established with a Minimal Requirement for Autologous Mononuclear Cells

    • Tom Ottenhoff, RenĂ© de Vries
    Pages 52-60

  5. Mycobacterium Leprae Specific Protein Antigens Defined by Cloned Human Helper T Cells

    • Tom Ottenhoff, RenĂ© De Vries
    Pages 61-67

  6. Cloned Suppressor T Cells from a Lepromatous Leprosy Patient Suppress Mycobacterium Leprae Reactive Helper T Cells

    • Tom Ottenhoff, RenĂ© De Vries
    Pages 68-76

  7. Molecular Localization and Polymorphism of HLA Class II Restriction Determinants Defined By Mycobacterium Leprae Reactive Helper T Cell Clones from Leprosy Patients

    • Tom Ottenhoff, RenĂ© De Vries
    Pages 77-100

  8. HLA-DR3 Molecules are the Products of an HLA Class II Immune Regulator Gene for Mycobacterium Leprae Predisposing to Tuberculoid Leprosy

    • Tom Ottenhoff, RenĂ© De Vries
    Pages 101-124

  9. Evidence for an HLA-DR4 Associated Immune Response gene for Mycobacterium Tuberculosis: A Clue to the Pathogenesis of Rheumatoid Arthritis?

    • Tom Ottenhoff, RenĂ© De Vries
    Pages 125-134

  10. General Discussion: Mycobacterium Leprae Specific Activation of Helper and Suppressor T Cells and its Regulation by HLA Class II Genes and Products

    • Tom Ottenhoff, RenĂ© De Vries
    Pages 135-151

  11. Short Summary

    • Tom Ottenhoff, RenĂ© de Vries
    Pages 152-153
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Keywords

About this book

Those who have had the privilege to visit the Sistine Chapel may remember the fres­ co painting of Jesus curing the leper (Marcus 1, 40-45). It seems that leprosy was not only known 2000 years ago but was also recognized as an important problem. Unfortunately, little has changed since then. Although leprosy is mainly known as an "import" disease in Europe and North America, in the greater part of the world it remains the problem it has always been, one of a stigmatizing disease comparable to the modern day pestilence, namely AIDS. Who could forget Durer's etch of a leper walking with a clapper to an­ nounce his presence, or the heartbreaking stories of patients, especially those with lepromatous leprosy, ousted by their own families to become social outcasts forced to beg for their food. This attitude is slowly changing and with this change the name of Mahatma Ghandi will always be connected and remembered.

Authors and Affiliations

  • Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands

    Tom Ottenhoff, René Vries

  • Armauer Hansen Research Institute, Addis Abeba, Ethiopia

    Tom Ottenhoff

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