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The Future of Predictive Safety Evaluation

In Two Volumes Volumes 2

  • Book
  • © 1987

Overview

Editors:
  1. A. N. Worden

    1. Cantab Group, Cambridge, England

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  2. D. V. Parke

    1. Department of Biochemistry, University of Surrey, Guildford, England

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    You can also search for this editor in PubMed   Google Scholar

  3. J. Marks

    1. Director of Medical Studies, Girton College, Cambridge, England

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-viii
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  2. Molecular Aspects of Toxicology

    1. Front Matter

      Pages 1-1
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    2. Molecular Aspects of Toxicology

      • D. V. Parke
      Pages 3-38

  3. Preclinical: in Vivo and Combined Approaches

    1. Front Matter

      Pages 39-39
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    2. The Organization of Preclinical and Premarketing Toxicity Testing

      • A. N. Worden
      Pages 41-46

    3. Animal Models of Responses Resulting from Short-term Exposures

      • V. K. Brown
      Pages 47-55

    4. Animal Models of Long Term Toxic Effects

      • A. N. Worden, S. R. Walker
      Pages 57-64

    5. Inhalation Aspects of Toxicology Testing

      • D. G. Clark
      Pages 65-76

    6. Testing For Reproductive Toxicity

      • A. B. G. Lansdown
      Pages 77-106

    7. Neurotoxicity

      • A. J. Dewar
      Pages 107-128

    8. Safety Evaluation — Carcinogenic Risks

      • J. H. Weisburger
      Pages 129-152

  4. Nutrition and Toxicological Prediction

    1. Front Matter

      Pages 153-153
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    2. Introduction — Laboratory Diets

      • D. L. Frape
      Pages 155-162

    3. Interaction of Drugs and Nutrients

      • D. L. Frape
      Pages 163-173

    4. Immune Function and Diet

      • D. L. Frape
      Pages 175-183

    5. Cancer and Diet

      • D. L. Frape
      Pages 185-195

    6. Influence of Diet on Longevity

      • D. L. Frape
      Pages 197-200

    7. Essential Fatty Acids, Prostaglandins and Anti-Inflammatory Drugs

      • D. L. Frape
      Pages 201-208

    8. Influence of Diet on Various Disorders

      • D. L. Frape
      Pages 209-236

    9. General Conclusions — Dietary Considerations Relative to Future Toxicology

      • D. L. Frape
      Pages 237-241
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Keywords

About this book

Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten­ tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi­ tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com­ pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.

Editors and Affiliations

  • Cantab Group, Cambridge, England

    A. N. Worden

  • Department of Biochemistry, University of Surrey, Guildford, England

    D. V. Parke

  • Director of Medical Studies, Girton College, Cambridge, England

    J. Marks

Bibliographic Information

  • Book Title: The Future of Predictive Safety Evaluation

  • Book Subtitle: In Two Volumes Volumes 2

  • Editors: A. N. Worden, D. V. Parke, J. Marks

  • DOI: https://doi.org/10.1007/978-94-009-3201-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: MTP Press Limited 1987

  • Softcover ISBN: 978-94-010-7936-5Published: 28 December 2011

  • eBook ISBN: 978-94-009-3201-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 320

  • Topics: Pharmacology/Toxicology

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