Overview
- Authors:
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James K. Whitesell
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Mark A. Minton
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Table of contents (19 chapters)
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- James K. Whitesell, Mark A. Minton
Pages 1-2
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- James K. Whitesell, Mark A. Minton
Pages 3-9
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- James K. Whitesell, Mark A. Minton
Pages 11-35
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- James K. Whitesell, Mark A. Minton
Pages 37-44
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- James K. Whitesell, Mark A. Minton
Pages 45-54
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- James K. Whitesell, Mark A. Minton
Pages 55-92
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- James K. Whitesell, Mark A. Minton
Pages 93-105
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- James K. Whitesell, Mark A. Minton
Pages 107-111
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- James K. Whitesell, Mark A. Minton
Pages 113-117
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- James K. Whitesell, Mark A. Minton
Pages 119-121
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- James K. Whitesell, Mark A. Minton
Pages 123-132
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- James K. Whitesell, Mark A. Minton
Pages 133-135
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- James K. Whitesell, Mark A. Minton
Pages 137-150
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- James K. Whitesell, Mark A. Minton
Pages 151-177
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- James K. Whitesell, Mark A. Minton
Pages 179-187
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- James K. Whitesell, Mark A. Minton
Pages 189-191
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- James K. Whitesell, Mark A. Minton
Pages 193-203
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- James K. Whitesell, Mark A. Minton
Pages 205-224
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- James K. Whitesell, Mark A. Minton
Pages 225-231
About this book
Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.