Myocardial Contrast Two-dimensional Echocardiography

1. Front Matter

   Pages I-XIV

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2. Introduction and general background

   • Samuel Meerbaum

   Pages 1-6

3. Development and validation of MC-2DE methodology

   • Samuel Meerbaum

   Pages 7-44

4. Contrast agents for myocardial perfusion studies

   • Shimon A. Reisner, Janine R. Shapiro, Antonio F. Amico, Richard S. Meltzer

   Pages 45-59

5. Significance and selection of contrast solution for myocardial contrast echocardiography

   • Klaus Berwing, Martin Schlepper, Hassan Bahavar, Arnd Buchwald

   Pages 61-84

6. Side effects and potential toxicity of myocardial contrast echocardiography

   • Shimon Reisner, Janine R. Shapiro, Richard S. Meltzer

   Pages 85-96

7. Ischemic ‘risk area’ determination using myocardial contrast two-dimensional echocardiography

   • Sanjiv Kaul

   Pages 97-115

8. Quantitation of regional myocardial perfusion using myocardial contrast two-dimensional echocardiography

   • Sanjiv Kaul

   Pages 117-139

9. Coronary venous myocardial contrast echocardiography

   • Samuel Meerbaum

   Pages 141-150

10. Assessment of contrast decay half life by myocardial contrast two-dimensional echocardiography

    • Folkert J. Ten Cate, Hua ging Huang

    Pages 151-162

11. Clinical trials with a new myocardial contrast agent

    • Klaus Berwing, Martin Schlepper, Peter Kremer, Hassan Bahavar

    Pages 163-180

12. Clinical evaluation of severity of coronary arterial stenosis by contrast echomyocardiography

    • Masayuki Matsumoto, Kiyoshi Yasui, Hiroshi Sekimoto, Takazo Minamino, Hiroshi Abe, Takenobu Kamada

    Pages 181-189

13. Clinical applications of myocardial contrast echocardiography

    • Janine R. Shapiro, Shimon A. Reisner, Richard S. Meltzer

    Pages 191-201

14. The issue of an intravenous MC-2DE methodology

    • Masayuki Matsumoto, Kiyoshi Yasui, Hiroshi Sekimoto, Masakatsu Fukushima, Hiroshi Abe, Takenobu Kamada

    Pages 203-217

15. Current perspective and future prospects

    • Samuel Meerbaum

    Pages 219-224

16. Back Matter

    Pages 225-236

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To our knowledge, this is the first book dealing exclusively with myocardial contrast two-dimensional echocardiography (MC-2DE), a new and exciting diagnostic methodology for assessment of myocardial perfusion, which has seen rapid development and has now entered the clinical stage. The experi­ mental research and human applications have been described in technical papers published in a variety of journals, but our objective is to provide the reader with a comprehensive and concentrated overview of the field and of the current state of the art. To facilitate appreciation of the significant ad­ vances made and issues yet to be resolved, we are pleased to have several well known specialists contribute their own assessment of specific aspects of MC- 20E and illustrate the method's principles as well as applications. We were faced with inevitable overlaps and some repetitions in the discussion of quan­ titative potentials or limilations of the methodology. Rather than strictly 'streamlining' the text, we decided to accept some redundancy in the interest of presenting a diversity of points of views, reflecting the current evolutionary state of MC-20E. Following a brief reference to the established clinical contrast echocardiog­ raphy, recent developments and validations of the specialized MC-2DE tech­ nique are reviewed, bearing in mind that the field is in a flux and some of the ongoing activities have not as yet been formally reported. Mechanisms of the echo contrast and several new agents are decribed next, and an additional chapter illustrates current thoughts-on optimizing the echo contrast medium.

• artery
• circulation
• contrast agent
• echocardiography
• ultrasound

`This book is a must for those interested in this subject matter.'
C. Visser, Dutch Magazine on Medicine, 20, 1990
`It was a pleasure reviewing this publication ... of interest to internists and cardiac physiologists ... this is a very important book, related to a rapidly emerging exciting technique. Reading it was both intellectually and scientifically satisfying.'
Cardiology, 77/4, 1990

• Woodland Hills, USA

  Samuel Meerbaum

• University of Rochester Medical Center, Rochester, USA

  Richard S. Meltzer

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