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Serotonin

From Cell Biology to Pharmacology and Therapeutics

  • Book
  • © 1990

Overview

Editors:
  1. Rodolfo Paoletti

    1. Fondazione Lorenzini, Milan, Italy

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  2. Paul M. Vanhoutte

    1. Mayo Clinic, Rochester, USA

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  3. Nicoletta Brunello

    1. Institute of Pharmacological Sciences, University of Milan, Italy

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  4. Franco M. Maggi

    1. Institute of Pharmacological Sciences, University of Milan, Italy

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Table of contents (85 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Serotonin Research: Historical Overview

    1. Serotonin Research: Historical Overview

      • M. M. Rapport
      Pages 1-4

  3. Molecular Mechanisms in Serotonin Mediated Response

    1. Front Matter

      Pages 5-5
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    2. Molecular Biology of the Serotonin Receptor Family

      • Paul R. Hartig
      Pages 7-11

    3. Molecular Structure of the Central 5-HT1A Receptor

      • M. Hamon, S. El Mestikawy, M. B. Emerit, H. Gozlan
      Pages 13-17

    4. Biochemical Characterization of the Cloned Human 5-HT1A Receptor Expressed in Mammalian Cells

      • A. Fargin, J. R. Raymond, R. J. Lefkowitz, M. G. Caron
      Pages 19-24

    5. Amplifying Effects of 5-Hydroxytryptamine on Human Platelets and Signal Transduction

      • D. De Chaffoy De Courcelles, F. De Clerck
      Pages 25-31

    6. Role of Phosphoinositide Hydrolysis and Protein Kinase C Activation in 5HT 2 Receptor Function in Smooth Muscle

      • Bryan L. Roth
      Pages 33-37

    7. Adenylate Cyclase-Linked 5-Hydroxytryptamine Receptors in the Brain

      • Saul Maayani, Merry R. Sherman
      Pages 39-51

    8. Characterization and Purification of the Neuronal 5-HT Transporter

      • S. Z. Langer, C. R. Lee, H. Esnaud, D. Graham
      Pages 53-60

    9. Structure and functional expression of cloned human liver MAO A and B

      • Jean Chen Shih, Nancy C. Lan
      Pages 61-65

  4. Physiology of Serotonergic System

    1. Front Matter

      Pages 67-67
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    2. Vascular System

      1. Amplifying Effect of Serotonin in the Control of Vascular Tone
        • W. J. Janssens, J. M. Van Nueten
        Pages 69-76
      2. Amplification Mechanisms in Platelet Activation
        • F. De Clerck, D. De Chaffoy De Courcelles
        Pages 77-80
      3. The Role of the Endothelium in the Cardiovascular Response to Serotonin
        • P. M. Vanhoutte, J. M. Van Nueten, W. J. Janssens
        Pages 81-96
      4. Endothelium-Dependent Relaxations to Serotonin: Signal Transduction and Effects of Diets
        • Hiroaki Shimokawa, Nicholas A. Flavahan, Paul M. Vanhoutte
        Pages 97-104
      5. 5-Hydroxytryptamine in Cerebrovascular Sympathetic Nerves and its Effect on Brain Vessels
        • Ch. Owman, J.-Y. Chang, J. E. Hardebo, H. W. M. Steinbusch
        Pages 105-115
      6. The 5-HT System of Blood Platelets: Physiological Variations and Pathophysiology in Essential Hypertension
        • A. Pletscher, N. Fetkovska, F. Ferracin, R. Amstein, F. R. Buehler
        Pages 117-121
      7. Serotonergic Regulation of Renin and Vasopressin Secretion
        • Louis D. Van de Kar, Janice H. Urban, Mark S Brownfield
        Pages 123-129
      8. 5 HT, Platelets and Experimental Atherosclerosis
        • Tony J. Verbeuren
        Pages 131-135
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Keywords

About this book

This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29 -Aprill, 1989. This meeting, held under the co-sponsorship of the Serotonin Club and the Fondazione Giovanni Lorenzini, represents the first attempt to bring together scientists fascinated by the complexity of the action of 5-hydroxytryptamine throughout the body and in various species. Hence this volume provides the reader with the unique overview of the sources, effects, receptors, physiological actions and pathological role of Serotonin. As such it will be of interest not only to the person devoting herorhis research efforts to the study of 5-hydroxytryptamine but also to all scholars and even clinicians wanting to know how the powerful monoamine can modulate cellular functions. To accelerate the publication of these proceedings the Editors and the publishers have selected the camera ready format and have avoided a lengthy refereeing process. Hence the scientific content of, and the opinions expressed in the chapters are the sole responsibility of the authors. The Editors Milan and Houston The Editors want to thank Mrs. H. Liepman and her staff at Kluwer for the prompt and efficient handling of the manuscripts.

Editors and Affiliations

  • Fondazione Lorenzini, Milan, Italy

    Rodolfo Paoletti

  • Mayo Clinic, Rochester, USA

    Paul M. Vanhoutte

  • Institute of Pharmacological Sciences, University of Milan, Italy

    Nicoletta Brunello, Franco M. Maggi

Bibliographic Information

  • Book Title: Serotonin

  • Book Subtitle: From Cell Biology to Pharmacology and Therapeutics

  • Editors: Rodolfo Paoletti, Paul M. Vanhoutte, Nicoletta Brunello, Franco M. Maggi

  • DOI: https://doi.org/10.1007/978-94-009-1912-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1990

  • Hardcover ISBN: 978-0-7923-0531-6Published: 31 December 1989

  • Softcover ISBN: 978-94-010-7353-0Published: 22 November 2011

  • eBook ISBN: 978-94-009-1912-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 668

  • Topics: Pharmacology/Toxicology, Medical Biochemistry, Cardiology

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