Advances in Mucosal Immunology

1. Front Matter

   Pages i-xxxv

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2. Local immunity: The human mucosa in health and disease

   1. Local immunity: The human mucosa in health and disease

      • P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P Krajci et al.

      Pages 1-12

3. Basic Mechanisms in Mucosal Immunology

   1. Front Matter

      Pages 13-13

      PDF

   2. Antigen Handling and Processing at Mucosal Surfaces

      1. Intestinal processing of soluble protein antigen

         • P W Bland, C V Whiting

         Pages 17-22

      2. Antigen handling in the intestine mediated by normal enterocytes

         • L Mayer, E Siden, S Becker, D Eisenhardt

         Pages 23-28

      3. Ultrastructural distribution of Class II MHC molecules in mucosal antigen presenting cells and their relationship to antigen uptake and processing

         • G Mayrhofer, L D J Spargo, G P Davidson, Z-H Huang

         Pages 29-33

      4. Mature la+ murine intestinal epithelial cells with APC activity share common antigens with gut interdigitating dendritic cells

         • D Kaiserlian, K Vidal, J P Revillard

         Pages 34-37

      5. Murine gut epithelial cells present antigen to specific T cell hybridoma

         • D Kaiserlian, K Vidal, M Blanc, J P Revillard

         Pages 38-39

      6. The expression of Class II major histocompatability antigens in the murine small intestine is not influenced by the oral administration of cholera toxin

         • A D Wilson, C R Stokes

         Pages 40-41

      7. Suppression of lymphoproliferation and interleukin-1 production by enterocyte-derived factors

         • G T Pang, R L Clancy, H A Saunders

         Pages 42-43

      8. Human colon epithelial cell lysates evoke monocyte chemotaxis

         • W Beeken, J Fabian, D Meyer, D Gump

         Pages 44-45

      9. Antigen handling at respiratory epithelial surfaces in the rat: a highly developed network of dendritic APC revealed by a novel tissue sectioning procedure

         • P G Holt, M A Schon-Hegrad, P G McMenamin

         Pages 46-47

      10. Induction of Class II MHC antigens in the rat digestive system after systemic application of recombinant gamma interferon

          • B Steiniger, P Falk, M Lohmüller, P H van der Meide

          Pages 48-49

      11. Rat intestinal lamina propria macrophages: characterisation and accesory role in ovalbumin-induced T cell proliferation

          • D M Kambarage, P W Bland

          Pages 50-51

      12. The effect of interferon gamma (IFN-<i>γ</i>) on MHC Class II (la) antigen by expression on the neonatal enterocyte

          • A Hughes, K J Bloch, D Gillen, A Bhan, V Giovino, P R Harmatz

          Pages 52-53

   3. Intraepithelial Lymphocytes and Lymphoepithelial Interactions

      1. Subsets of gamma/delta T cells in human intestinal epithelium

         • J Spencer, P G Isaacson, T C Diss, T T MacDonald

         Pages 57-60

      2. Increased numbers of T cell receptor gamma/delta bearing lymphocytes in the epithelium of coeliac patients

         • E Savilahti, A Arato, M Verkasalo

         Pages 61-66

      3. The gamma/delta T cell receptor (TCR) is expressed on less than 50% of intraepithelial lymphocytes (IEL) in human intestine

         • R Ullrich, H Schieferdecker, C Brunn, E O Riecken, M Zeitz

         Pages 67-68

      4. Expression of T cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa

         • L K Trejdosiewicz, C J Smart, D J Oakes, A Calabrese, P D Howdle, A W Boylston

         Pages 69-70

      5. Analysis of intestinal intraepithelial lymphocytes in athymic (nude) and SCID mice

         • B de Geus, L D Shulz, M van der Enden, J Coolen, J Rozing

         Pages 71-76

The immunology of mucosal surfaces is one of the most exciting and relevant areas of medical veterinary and dental research since it applies basic research to tissues in­ volved in everyday defence against microbes and against environmental and food antigens. This book is based on the contributions presented at the International Con­ gress of Mucosal Immunology, held in London in July 1989 and organised by the Mu­ cosal Immunology Affinity Group of the British Society for Immunology. The meet­ ing was attended by over 500 delegates from 27 countries, including virtually all of the leading investigators in the field. The contents give comprehensive and up-to­ date information on such topics as antigen presentation and processing in the gut, mucosal vaccines in man and animals, HIV infection in the gut, the role of yo T cells in the gut epithelium, recent advances in inflammatory bowel disease and coeliac dis­ ease, the role of cytokines in the regulation of the IgA response, mucosal mast cells and cell migration. The contributions reflect the rapid pace of research in mucosal immunology, and the great strides which are taking place in the understanding of the immunology, molecular biology and biochemistry of host response at mucosal sur­ faces.

• diseases
• immunity
• immunology

• Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK

  Thomas T MacDonald

• Department of Oral Medicine and Pathology, Guy’s Hospital, London, UK

  Stephen J Challacombe

• Department of Veterinary Medicine, The University, Bristol, UK

  Paul W Bland, Christopher R Stokes

• Department of Medicine, St James’s University Hospital, London, UK

  Richard V Heatley

• Department of Bacteriology and Immunology, The University, Glasgow, UK

  Allan Mcl Mowat

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