Skip to main content
SpringerLink
Log in
Book cover

Laboratory animals in vaccine production and control

Replacement, reduction and refinement

  • Book
  • © 1988

Overview

Authors:
  1. Coenraad F. M. Hendriksen

    1. National Institute of Public Health and Environmental Protection, The Netherlands

    View author publications

    You can also search for this author in PubMed   Google Scholar

Part of the book series: Developments in Hematology and Immunology (DIHI, volume 20)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Introduction

    • Coenraad F. M. Hendriksen
    Pages 1-2

  3. Animal Experimentation and the Development of Vaccines: A Brief Historical Outline

    • Coenraad F. M. Hendriksen
    Pages 3-7

  4. The Historical Role of Animal Experiments in the Development of Diphtheria Prophylaxis

    • Coenraad F. M. Hendriksen
    Pages 9-22

  5. Vaccine Development and Production

    • Coenraad F. M. Hendriksen
    Pages 23-35

  6. Experimental Animals and Animal Experiments

    • Coenraad F. M. Hendriksen
    Pages 37-49

  7. Animal Experimentation and its Shortcomings

    • Coenraad F. M. Hendriksen
    Pages 51-55

  8. Alternatives to and in Animal Experimentation

    • Coenraad F. M. Hendriksen
    Pages 57-62

  9. Opportunities for Replacement, Reduction or Refinement: Human Bacterial Vaccines

    • Coenraad F. M. Hendriksen
    Pages 63-92

  10. Opportunities for Replacement, Reduction and Refinement: Human Viral Vaccines

    • Coenraad F. M. Hendriksen
    Pages 93-113

  11. Opportunities for Replacement, Reduction or Refinement: Poultry Vaccines

    • Coenraad F. M. Hendriksen
    Pages 115-124

  12. Opportunities for Replacement, Reduction or Refinement: Veterinary Vaccines for Mammals

    • Coenraad F. M. Hendriksen
    Pages 125-137

  13. Replacement, Reduction or Refinement: An Indirect Approach

    • Coenraad F. M. Hendriksen
    Pages 139-144

  14. Future Prospects

    • Coenraad F. M. Hendriksen
    Pages 145-149

  15. Final Comments and Recommendations

    • Coenraad F. M. Hendriksen
    Pages 151-157

  16. Back Matter

    Pages 158-158
    Download chapter PDF
Back to top

Keywords

About this book

9. REFERENCES 90 CHAPTER 9: OPPORTUNITIES FOR REPLACEMENT, REDUCTION AND REFINEMENT: HUMAN VIRAL VACCINES 93 1. INTRODUCTION 93 2. TESTS FOR EXTRANEOUS MICROORGANISMS 94 3. MUMPS VACCINE . . . 94 4. HEPATITIS B VACCINE 95 4. 1. Test for freedom from live hepatitis virus 95 4. 2. Potency test 95 5. INFLUENZA VACCINE 96 5. 1. Potency test 96 5. 2. Abnormal-toxicity test 96 6. MEASLES VACCINE. . . . . 96 6. 1. Tests for extraneous agents 97 6. 1. 1. Test for Mycobacterium tuberculosis 97 6. 1. 2. Test for extraneous viruses 97 6. 2. Abnormal-toxicity test 98 7. POLIOMYELITIS VACCINE. . . 99 7. A. Inactivated poliomyelitis vaccine 99 7. A. l. Production. . . . . . 99 7. A. 2. Test for residual live virus 99 7. A. 3. Tests for extraneous agents 100 7. A. 3. l. Test for Mycobacterium tuberculosis . . . . . 100 7. A. 3. 2. Test for extraneous viruses 100 7. A. 4. Tumourigenicity test. . . . . 100 XII 7 . A. 5. Potency test . . . . . . . 101 7. A. 6. Test for abnormal toxicity 102 7. B. Live, oral poliomyelitis vaccine 103 7. B. l. Test for extraneous agents 103 7. B. 2. Test for neurovirulence 105 7. B. 3. Test for abnormal toxicity 106 8. RABIES VACCINE 106 8. 1. Production 106 8. 2. Test for residual live virus 107 8. 3. Tests for extraneous microorganisms 107 8. 3. 1. Test for Mycobacterium tuberculosis 107 8. 3. 2. Tests for extraneous viruses 108 8. 3. 2. 1. In dogs 108 8. 3. 2. 2.

Reviews

`All who work in the area of vaccine production and control or who are concerned for the welfare of animals should read this book and act on its recommendations.'
Australian Veterinary Journal, 67 (12) December 1990

Authors and Affiliations

  • National Institute of Public Health and Environmental Protection, The Netherlands

    Coenraad F. M. Hendriksen

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation