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New Developments in Antirheumatic Therapy

  • Book
  • © 1989

Overview

Editors:
  1. K. D. Rainsford

    1. Department of Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Canada

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  2. G. P. Velo

    1. Institute of Pharmacology, University of Verona, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Inflammation and Drug Therapy Series (IDTH, volume 3)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
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  2. Recent developments in antirheumatic therapy

    • P. Nash, B. L. Hazleman
    Pages 1-28

  3. Osteoarthritis: a metabolic disorder

    • C. W. Denko
    Pages 29-35

  4. Concepts of the mode of action and toxicity of anti-inflammatory drugs. A basis for safer and more selective therapy, and for future drug developments

    • K. D. Rainsford
    Pages 37-92

  5. Animal models of arthritic disease: influence of novel compared with classical antirheumatic agents

    • I. M. Hunneyball, M. E. J. Billingham, K. D. Rainsford
    Pages 93-131

  6. Novel eicosanoid inhibitors

    • Lisa A. Marshall, Joseph Chang
    Pages 133-151

  7. New steroidal anti-inflammatory drugs

    • Henry J. Lee, Ann S. Heiman, Irach B. Taraporewala
    Pages 153-186

  8. Oxyradicals, inflammation and drugs acting on oxyradical production

    • Dennis V. Parke, Andrew M. Symons, Ann L. Parke
    Pages 187-206

  9. Gold(I)-thiolates: slow-acting anti-arthritic drugs

    • Davin R. Haynes, Michael W. Whitehouse
    Pages 207-233

  10. Do platelet activating factor antagonists have a potential role in the therapy of rheumatoid arthritis?

    • C. P. Page, A. J. Coyle
    Pages 235-253

  11. Interleukin 1: past, present, future

    • Michael C. Powanda, Elizabeth D. Moyer
    Pages 255-276

  12. The T cell as a therapeutic target

    • Ivan G. Otterness, Marcia L. Bliven
    Pages 277-304

  13. Superoxide dismutase modifications for anti-inflammatory therapy

    • F. M. Veronese, A. Conforti, G. P. Velo
    Pages 305-314

  14. Back Matter

    Pages 315-328
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Keywords

About this book

At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions. This is be­ cause we now recognise that although some advances have been made with the development of a large range of non-steroidal and steroidal drugs during the past two decades or so, we now recognise that many, if not all, of these have rather limited effects on many of the disease processes which underlie the manifestations of the various rheumatic states. Advances in molecular bi- 010gy in the past 5-10 years have enabled these tools to be applied extensive­ ly for developing further our understanding of the rheumatic disease processes. In some cases these molecular tools (e. g. ,),-interferon, interleukin- 2, T-cell antibodies) have been directly employed as therapies themselves. While the outcome from trials with such agents in rheumatoid arthritis in particular has not been as would have been hoped, these results as with cy­ closporin A and low-dose methotrexate in the therapy of rheumatoid arth­ ritis have given us important indications for the approach employing what are generally described as "immunomodulators" to control this disease. But this may not be the same type of approach which is desirable for all types of rheumatic conditions. Indeed, even the way which the present range of drugs and other therapies are applied may not be the most effective and safe means of treating different types of arthritic conditions.

Editors and Affiliations

  • Department of Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Canada

    K. D. Rainsford

  • Institute of Pharmacology, University of Verona, Italy

    G. P. Velo

Bibliographic Information

  • Book Title: New Developments in Antirheumatic Therapy

  • Editors: K. D. Rainsford, G. P. Velo

  • Series Title: Inflammation and Drug Therapy Series

  • DOI: https://doi.org/10.1007/978-94-009-1253-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1989

  • Softcover ISBN: 978-94-010-7056-0Published: 20 September 2011

  • eBook ISBN: 978-94-009-1253-3Published: 06 December 2012

  • Series ISSN: 0923-9405

  • Edition Number: 1

  • Number of Pages: 272

  • Topics: Pharmacology/Toxicology, Rheumatology

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