Fundamental Aspects of Cancer

1. Front Matter

   Pages i-x

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2. The Biology of Human Cancer, and the Development of a Rational Basis for Treatment

   • Arthur S. Levine

   Pages 1-22

3. Organ Culture: Use in Experimental Oncology for Comparisons Among Species

   • David G. Kaufman, Gene P. Siegal

   Pages 23-27

4. Overview of Current Understanding of Tumor Spread

   • Ronald H. Goldfarb, Kenneth W. Brunson

   Pages 28-32

5. Intraspecies and Interspecies Comparison

   • H. E. Kaiser

   Pages 33-34

6. The Life Span of Mammals: A Comparison

   • H. E. Kaiser, J. Paradiso, M. Jones

   Pages 35-40

7. The Culmination of Neoplastic Development in the Mammal

   • H. E. Kaiser

   Pages 41-42

8. The Influence of the Body Structure on Tumor Development

   • H. E. Kaiser

   Pages 43-46

9. The Evolution of Diversity within Tumors and Metastases

   • James E. Talmadge

   Pages 47-64

10. Neoplastic Heterogeneity and Clinical Chemotherapy

    • Stephen K. Carter

    Pages 65-72

11. The Attraction of Wandering Metastatic Cells

    • James Varani, J. Philip McCoy, Peter A. Ward

    Pages 73-83

12. Tumor-Cell Interactions with Blood Vessels during Cancer Metastasis

    • Peter A. Netland, Bruce R. Zetter

    Pages 84-97

13. Comparative Importance of the Lymphatic System during Neoplastic Progression: Lymphohematogenous Spreading

    • H. E. Kaiser

    Pages 98-133

14. Immunological Control of Tumor Metastases

    • E. L. Gorelik, R. B. Herberman

    Pages 134-143

15. Role of Macrophages in Recognition and Destruction of Metastatic Cells

    • Rajiv Nayar, Isaiah J. Fidler

    Pages 144-155

16. Metastases from Metastasis: Clinical Relevance in Human Cancer

    • John D. Crissman

    Pages 156-161

17. Treatment Research in Cancer

    • Gregory A. Curt, Bruce A. Chabner

    Pages 162-170

18. Chemotherapy from Animals to Man

    • Takao Ohnuma, James F. Holland

    Pages 171-191

19. Therapy of Metastasis in Animal Models

    • Vincent A. Pollack

    Pages 192-200

20. Back Matter

    Pages 201-211

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Individual neoplastic diseases often show discrete growth direct effect of tumor metastases or to adverse consequences patterns subject to many modifications according to the associated with these therapeutic modes (e.g., complications stage of the disease, the species involved and the tumor type of immunosuppression which can lead to mortality arising concerned. Primary neoplasms are less difficult to treat in from infectious disease). contrast to secondary neoplasms. The chief type of secon­ It is therefore quite clear that there is a crucial need for dary neoplastic growth, metastasis, is also comparatively new methods for the detection of micrometastases and the development of new modalities for the treatment of estab­ less well understood. Phylogenetically, metastasis attains its highest level of development in the mammal and is best lished metastases. It is likely that such modalities must known in man, but is still far from being understood. overcome tumor heterogeneity and drug resistance to yield new therapeutic modalities with improved margin of safety The process of cancer growth and progression, from the initiation of neoplastic transformation of normal cells to the and efficacy over currently available anti-neoplastic drugs.

• cancer

• Pittsburgh Cancer Institute, Pittsburgh, USA

  Ronald H. Goldfarb

• Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

  Ronald H. Goldfarb

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