Skip to main content
SpringerLink
Log in

Cyclosporin

Mode of Action and Clinical Applications

  • Book
  • © 1989

Overview

Editors:
  1. Angus W. Thomson

    1. Immunopathology Laboratory, Department of Pathology, University of Aberdeen, Aberdeen, Scotland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Inhibitory effects of cyclosporin A on lymphocyte activation

    • John E. Kay
    Pages 1-23

  3. Effect of cyclosporin A on the immune response: pivotal role of the interleukin-2/ interleukin-2 receptor autocrine pathway

    • Allan D. Hess
    Pages 24-33

  4. Influence of CsA on humoral immunity and on B lymphocyte activation

    • Iris Motta, Paolo Truffa-Bachi
    Pages 34-49

  5. The influence of cyclosporin A on T cell activation, cytokine gene expression and cell-mediated immunity

    • Angus W. Thomson, Janet I. Duncan
    Pages 50-81

  6. Cyclosporin A and tolerance induction in experimental animals

    • Susan M. L. Lim, David J. G. White
    Pages 82-111

  7. Prevention of graft rejection by cyclosporin A in man

    • Michael C. Jones, Graeme R. D. Catto
    Pages 112-144

  8. Cyclosporin A and bone marrow transplantation

    • Kerry Atkinson
    Pages 145-158

  9. Cyclosporin A and intraocular inflammatory disease

    • John V. Forrester, Janet Liversidge, Hamish M. Towler
    Pages 159-180

  10. Cyclosporin A in insulin-dependent diabetes

    • Jean-François Bach
    Pages 181-190

  11. Cyclosporin A and skin disease

    • Anne V. Powles, Barbara S. Baker, Lionel Fry
    Pages 191-212

  12. Cyclosporin A (Sandimmun®) in autoimmune disorders

    • Beat von Graffenried, David Friend, Nicholas Shand, Wilfried Scheiss, Pentti Timonen
    Pages 213-251

  13. Pharmacokinetics of cyclosporin A

    • Joachim Grevel, Barry D. Kahan
    Pages 252-266

  14. Cyclosporin A Metabolism and Drug Interactions

    • M. Danny Burke, Fiona Macintyre, D. Cameron, Paul H. Whiting
    Pages 267-302

  15. Pathological effects of cyclosporin A in experimental models

    • Paul H. Whiting, Angus W. Thompson
    Pages 303-323

  16. Pathological effects of cyclosporin A in clinical practice

    • Sathia Thiru
    Pages 324-364

  17. Back Matter

    Pages 365-372
    Download chapter PDF
Back to top

Keywords

About this book

Cyclosporin has had a remarkable effect on clinical organ transplantation. Prior to its introduction, considerable advances had been made in the grafting of vital organs, particularly the kidney, heart and liver. In many developed countries, however, transplantation was not considered wo-rthwhile in terms of gain for the investment of resources. The improved results of kidney grafts following the use of cyclosporin has changed this attitude. For all types of organ transplantation, cyclosporin has resulted in an improvement of functional graft survival and has allowed a reduction in steroid dose and, in some cases, no steroids at all. It has permitted the first successful experimental transplantation of the heart and lungs in primate species by Reitz and colleagues and their results were applied directly to the clinic. It was largely due to the introduction of cyclosporin that the Washington Consensus Meeting on Liver Transplantation came to a favourable recommendation and the result has been the proliferation of units performing liver transplantation, approximately fifty in North America and another fifty in Europe, where previously there had been a handful. Having been involved in cyclosporin for organ grafting from the beginning, I have been able to witness these developments which have far exceeded my expectations once the nephrotoxicity of cyclosporin was demonstrated in man. It is fitting that Dr.

Editors and Affiliations

  • Immunopathology Laboratory, Department of Pathology, University of Aberdeen, Aberdeen, Scotland

    Angus W. Thomson

Bibliographic Information

  • Book Title: Cyclosporin

  • Book Subtitle: Mode of Action and Clinical Applications

  • Editors: Angus W. Thomson

  • DOI: https://doi.org/10.1007/978-94-009-0859-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1989

  • Softcover ISBN: 978-94-010-6874-1Published: 26 September 2011

  • eBook ISBN: 978-94-009-0859-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 384

  • Topics: Immunology, Surgery, Pathology, Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation