Lymphoproliferative Diseases

1. Front Matter

   Pages i-x

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2. Introduction

   • D. B. Jones, D. H. Wright

   Pages 1-3

3. Diagnosis of Leukaemia

   • J. M. Davies, J. C. Cawley

   Pages 5-13

4. The Diagnosis and Classification of Malignant Lymphomas

   • D. H. Wright

   Pages 15-29

5. Analysis of Immunoglobulin Changes in Lymphoproliferative Diseases

   • J. L. Smith, F. K. Stevenson

   Pages 31-52

6. Immunoenzymatic Analysis of Haematological and Cytological Preparations

   • A. K. Ghosh, W. N. Erber

   Pages 53-72

7. Cell-mediated Immunity in Lymphomas

   • P. L. Amlot

   Pages 73-90

8. The Origin of the Reed-Sternberg Cell

   • D. B. Jones

   Pages 91-106

9. Chronic-type B-Iymphocytic Leukaemias

   • P. Richardson, J. Gordon

   Pages 107-122

10. Malignant Lymphoma of Mucosa Associated Lymphoid Tissue (Malt)

    • P. G. Isaacson, J. Spencer

    Pages 123-143

11. T-cell Neoplasia

    • A. D. Ramsay, W. J. Smith

    Pages 145-163

12. Tumours of the Macrophage Series

    • Su-Ming Hsu

    Pages 165-186

13. Immunostaining Methods for Frozen and Paraffin Sections

    • B. L. Mepham, K. J. M. Britten

    Pages 187-211

14. Back Matter

    Pages 213-216

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Recent developments in the field of cellular pathology and molecular biology have had a major impact on our ability to diagnose lymphoreticular disease and on our understanding of many of the disease processes which contribute to lymphoreticular pathology. Twenty years ago, the immunological analysis of lymphoid proliferations was in its infancy. The techniques available, such as sheep red blood cell rosetting and immune adherence to frozen sections, now appear unbelievably crude when compared with our ability to accurately phenotype lymphocytes in suspension, in frozen section and, more recently, in formalin-fixed, paraffin-embedded tissue biopsies. Four international work­ shops have also standardized the nomenclature for the wide range of lineage­ restricted and lineage-related monoclonal antibodies available, and have provided a basis for the sophisticated phenotypic analysis of lymphoid neoplasms in even the smallest routine laboratories. Our concepts relating to the pathogenesis of a number of human lymphomas have also changed substantially, and this has been aided by the development of systems for the classification of human lymphoma which are firmly based in our knowledge of the differentiation and biological behaviour of normal lymphoreticular cells. In this monograph, we present contributions from many authors examining both leukaemia and lymphoma from an immunological perspec­ tive. It is our hope that some of these contributions will be of practical value in the laboratory investigation and diagnosis of lymphoreticular disease. Other contributions record our conceptual understanding of the histogenesis and pathogenesis of human lymphoma.

• cell
• classification
• diseases
• immunoglobulin
• lymphoma
• tumor

• Level E, South Block Southampton General Hospital, University Pathology, Southampton Hant, UK

  D. B. Jones

• University Department of Pathology, Southampton General Hospital, Southampton Hant, UK

  D. H. Wright

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