General Methods in Biomarker Research and their Applications

1. Front Matter

   Pages i-xxix

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2. General Aspects: Techniques and Overviews

   1. Front Matter

      Pages 1-1

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   2. High-Throughput Approaches to Biomarker Discovery and Challenges of Subsequent Validation

      • Boris Veytsman, Ancha Baranova

      Pages 3-16

   3. Mass Spectrometry for Biomarker Development

      • Chaochao Wu, Tao Liu, Erin S. Baker, Karin D. Rodland, Richard D. Smith

      Pages 17-48

   4. Mass Spectrometry-Based Lipidomics for Biomarker Research

      • Chunxiu Hu, Jia Li, Guowang Xu

      Pages 49-74

   5. Toxicogenomic and Pharmacogenomic Biomarkers for Drug Discovery and Personalized Medicine

      • Takeki Uehara, Yuping Wang, Weida Tong

      Pages 75-109

   6. Glycome as Biomarkers

      • Yasuro Shinohara, Jun-ichi Furukawa, Yoshiaki Miura

      Pages 111-140

   7. Flow Cytometry as Platform for Biomarker Discovery and Clinical Validation

      • Olga Millán, Mercè Brunet

      Pages 141-164

   8. Biomarkers in Urine and Use of Creatinine

      • Yutaka Tonomura, Mitsunobu Matsubara, Itsuro Kazama

      Pages 165-186

   9. Formalin-Fixed Paraffin-Embedded Tissue (FFPET) Sections for Nucleic Acid-Based Analysis in Biomarker Discovery and Early Drug Development

      • Sabine Lohmann, Beatrix Bahle, Andrea Herold, Julian Schuster

      Pages 187-219

3. Specific Analytes and Their Application

   1. Front Matter

      Pages 221-221

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   2. Macrophage Inflammatory Protein-1 Alpha (MIP-1 alpha)/CCL3: As a Biomarker

      • Ishita Bhavsar, Craig S. Miller, Mohanad Al-Sabbagh

      Pages 223-249

   3. Novel Prognostic Biomarker, Pfetin, in Gastrointestinal Stromal Tumors: Proteomics Study

      • Tadashi Kondo

      Pages 251-266

   4. Pentraxin 3 as Biomarker

      • Halil Yaman, Emin Ozgur Akgul, Yasemin Gulcan Kurt, Erdinc Cakir

      Pages 267-290

   5. Salivary Amylase as a Preoperative Marker of Anxiety in Perioperative Medicine

      • Tiphaine Robert-Mercier, Monique Dehoux, Dan Longrois, Jean Guglielminotti

      Pages 291-311

   6. Urinary Hydrogen Peroxide as Biomarker

      • Da-Hong Wang, Keiki Ogino, Yoshie Sato, Noriko Sakano, Masayuki Kubo, Kei Takemoto et al.

      Pages 313-331

   7. Creatine as Biomarker

      • Antonia Ribes, Sonia Pajares, Ángela Arias, Judit García-Villoria

      Pages 333-361

   8. Guanylyl Cyclase C as a Biomarker

      • Peter S. Chang, Terry Hyslop, Scott A. Waldman

      Pages 363-381

   9. Isoprostanes as Biomarkers of Disease and Early Biological Effect

      • Roberto Bono, Valeria Romanazzi

      Pages 383-404

   10. Cyclophilin A: Novel Biomarker for Oxidative Stress and Cardiovascular Diseases

       • Kimio Satoh, Hiroaki Shimokawa

       Pages 405-438

The well-being of humankind is dependent upon advances in biological and clinical sciences. For many diseases, an early diagnosis and objective measures of outcomes are essential for reducing mortality and morbidity. Part of this package entails the appropriate use of biomarkers. These are biological indicators which often are used routinely in the clinical setting. Recent advances in the chemical and physical sciences have enabled new biomarkers to be developed. This does not mean that traditional markers are redundant as detailed investigations have identified both limitations and advantages in their usage as well as new applications.  This book General Methods in Biomarker Research and their Applications combines both traditional, new and emerging biomarkers in a single publication. The chapters contained in this book have wide applicability to many diseases.

• Application to prognosis
• Biomarkers in disease
• Cancer Research
• Discovery of biomarkers
• High throughput technologies

• Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom

  Victor R. Preedy

• Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

  Vinood B. Patel

Professor Victor R. Preedy is a senior faculty member of King's College London (Professor of Nutritional Biochemistry) and King's College Hospital (Professor of Clinical Biochemistry). He is attached to both the Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics. He is also Director of the Genomics Centre and a member of the School of Medicine. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1993 he gained his second doctoral degree, for his outstanding contribution to protein metabolism in health and disease. He has received membership and fellowship of a number of academic and professional bodies in the UK, including the Royal College of Pathologists, the Royal Institute of Public Health, and the Royal Society of Chemistry. Professor Preedy has published over 570 articles, which includes 165 peer-reviewed manuscripts based on original research, 100 reviews and over 50 books and book volumes.

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