Skip to main content
SpringerLink
Log in

Evolution-adjusted Tumor Pathophysiology:

The Novel Language of Tumor Biology

  • Book
  • © 2013

Overview

Editors:
  1. Albrecht Reichle

    1. , Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Applied systems biology
  • Personalizing tumor therapy with novel methodological approaches
  • Drafting the non-genomic counterpart of the genome: Rationalizations constituting tumor-associated normative notions (angiogenesis, inflammation, immune response etc.)
  • Reconstructing and operationalizing starting points for an evolution theory
  • Evolution-adjusted tumor pathophysiology as novel clinical and pharmaceutical technology for bioengineering tumor response

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (23 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  3. Combined Modularized Therapies for Metastatic Tumors: Pointing to Central Problems of Communication Among ‘Systems Participators’ in Tumors

    1. Front Matter

      Pages 11-11
      Download chapter PDF

  4. Combined Modularized Therapies for Metastatic Tumors: Pointing to Central Problems of Communication Among ‘Systems Participators’ in Tumors

    1. Applied Systems Biology for the Control of Metastatic Cancer: Therapeutic Top-Down Strategy for Targeting the Tumors’ Normativity

      • A. Reichle, G. C. Hildebrandt
      Pages 13-28

    2. Targeting the Proangiogenic Network in Angiosarcomas: Biomodulatory Therapy

      • S. Singer, L. Größer
      Pages 29-33

    3. Long-Term Results of Combined Modularized, Immune-Modulatory, Angiostatic, and Antiinflammatory Therapy in Systemically Pre-Treated Multi-Systems Langerhans Cell Histiocytosis

      • A. Reichle, M. Vogelhuber, T. Vogt, L. Kunz-Schughart, T. Bretschneider, K. Bross et al.
      Pages 35-45

    4. Redirecting and Modulating Rationalizations of Tumor-Immanent Normative Functions in Castration-Resistant Prostate Cancer

      • M. Vogelhuber, S. Feyerabend, A. Stenzl, T. Suedhoff, M. Schulze, J. Huebner et al.
      Pages 47-66

  5. Social Engineering: Biomodulation, Either Endogenously Initiated or by Implementation of Non-normative Boundary Conditions

    1. Front Matter

      Pages 67-67
      Download chapter PDF

    2. Non-Hierarchically Organized Operations in Malignancies: Stromal Dysfunction Induces and Maintains Hematopoietic Malignancies

      • J. Grassinger, R. Schelker
      Pages 69-90

    3. Biomodulatory Therapy Approaches in Renal Clear Cell Carcinoma: A Perspective

      • Albrecht Reichle
      Pages 91-100

    4. Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction

      • Verena Paulitschke, Silke Gruber, Elisabeth Hofstätter, Verena Haudek-Prinz, Philipp Klepeisz, Nikolaus Schicher et al.
      Pages 101-141

  6. The Tumors’ Normativity: Reconstructing and Operationalizing Starting Points for an Evolution Theory

    1. Front Matter

      Pages 143-143
      Download chapter PDF

  7. The Tumors’ Normativity: Reconstructing and Operationalizing Starting Points for an Evolution Theory

    1. The Philosophical Quest of a Cancer Cell: Redefining Existentialism

      • Ellora Sen
      Pages 145-154

    2. The Tumor’s Normativity: Normative Structures, Action Norms and Decision Maxims as Therapeutic Targets for Tumor Therapy

      • Albrecht Reichle, Joachim Hahn
      Pages 155-167

    3. Criticizable Claims for the Validity of Communication Acts in Biological Systems: Therapeutic Implications in Cancer

      • Albrecht Reichle, Christopher Gerner, Guy Haegeman
      Pages 169-187
Back to top

Keywords

About this book

Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.

Editors and Affiliations

  • , Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany

    Albrecht Reichle

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation