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The Tumor Immunoenvironment

  • Book
  • © 2013

Overview

Editors:
  1. Michael R. Shurin

    1. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, USA

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  2. Viktor Umansky

    1. , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Heidelberg, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Anatoli Malyguine

    1. , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, USA

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    You can also search for this editor in PubMed   Google Scholar

  • This is a unique and very first book summarizing current knowledge on immune cell functioning in cancer
  • Focus on both experimental animal results and human clinical trials
  • Prepared logically linked chapter in one comprehensive review of the field
  • Includes supplementary material: sn.pub/extras

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Role of the Immunological Environment in Cancer Initiation, Development and Progression

    • Anatoli Malyguine, Viktor Umansky, Michael R. Shurin
    Pages 1-12

  3. Tumor Microenvironment and Immunoenvironment

    1. Front Matter

      Pages 13-13
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    2. The Metastatic Microenvironment

      • Shelly Maman, Isaac P. Witz
      Pages 15-38

    3. Tumor Infiltration by Immune Cells: Pathologic Evaluation and a Clinical Significance

      • Dmitriy W. Gutkin
      Pages 39-82

    4. Immunologic Interpretation of Cancer Biology: Impact on Clinical Outcome

      • Maria Libera Ascierto, Francesco M. Marincola, Ena Wang
      Pages 83-104

  4. Developmental Characteristics of the Tumor Immunoenvironment

    1. Front Matter

      Pages 105-105
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    2. Development of Antitumor Cellular Immunity

      • M. J. P. Welters, S. H. van der Burg
      Pages 107-133

    3. The Versatile World of Inflammatory Chemokines in Cancer

      • Tal Leibovich-Rivkin, Yaeli Lebel-Haziv, Shalom Lerrer, Polina Weitzenfeld, Adit Ben-Baruch
      Pages 135-175

    4. Inflammation, Tumor Progression, and Immune Suppression

      • Suzanne Ostrand-Rosenberg, Pratima Sinha
      Pages 177-196

    5. Pleiotropic and Differential Functions of IL-1α and IL-1β Shape the Tumor Microenvironment and Affect the Outcome of Malignancies

      • Ron N. Apte, Elena Voronov
      Pages 197-222

    6. Impact of Obesity and Aging on the Tumor Immuno-Environment

      • Annie Mirsoian, Gail D. Sckisel, Anthony E. Zamora, William J. Murphy
      Pages 223-250

  5. Tumor Escape from Immune Recognition

    1. Front Matter

      Pages 251-251
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    2. MHC Class I Antigens and the Tumor Microenvironment

      • Natalia Aptsiauri, Teresa Cabrera, Angel Garcia-Lora, Francisco Ruiz-Cabello, Federico Garrido
      Pages 253-286

    3. Tumor-Produced Immune Regulating Factors

      • Mads Hald Andersen, Jürgen C. Becker, Per thor Straten
      Pages 287-306

    4. Roles of Signaling Pathways in Cancer Cells and Immune Cells in Generation of Immunosuppressive Tumor-Associated Microenvironments

      • Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto, Tomoko Iwata-Kajihara et al.
      Pages 307-323

    5. T Cell Mulfunction in the Tumor Environment

      • Eitan Yefenof
      Pages 325-338

    6. Signaling of Tumor-Induced Immunosuppression of Dendritic Cells

      • Yong Lu, Jing Yang, Qing Yi
      Pages 339-360

    7. Tumor Microenvironment may Shape the Function and Phenotype of NK Cells Through the Induction of Split Anergy and Generation of Regulatory NK Cells

      • Anahid Jewett, Han-Ching Tseng
      Pages 361-381

  6. Immune Regulators in the Tumor Immunoenvironment

    1. Front Matter

      Pages 383-383
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Keywords

About this book

Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.

Editors and Affiliations

  • Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, USA

    Michael R. Shurin

  • , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Heidelberg, Germany

    Viktor Umansky

  • , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, USA

    Anatoli Malyguine

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